Search Results - analgesic

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Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouse Slc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance. These mice permit the study of elevated presynaptic choline transporter protein in vivo, expressed solely in cholinergic neurons due to the BAC...

Published: 4/18/2016 | Inventor(s):

Keywords(s): Analgesic, Cardiovascular, Inflammatory/Immune, Metabolic Disorders/ Diabetes, Neuroscience/Neurology

Category(s): Research Tools

Small molecule-GIRK Potassium Channel Modulators are Anxiolytic Therapeutics

Summary The G-protein activated, inward-rectifying potassium (K+) channels, “GIRKs”, are a family of ion channels that has been the focus of intense research interest for nearly two decades. GIRK has been shown to play important roles in the pathophysiology of diseases such as anxiety, epilepsy, Down’s syndrome, pain perception and...

Published: 6/21/2024 | Inventor(s): Charles Weaver, P. Jeffrey Conn

Keywords(s): Analgesic

Category(s): Therapeutics