Search Results - research+tools

40 Results

Sort By:

Novel Curcumin Derivatives with Enhanced Anti-Inflammatory Properties

SUMMARY This technology comprises two novel curcumin derivatives - compounds D3 and D4 - with potent anti-inflammatory properties. These compounds effectively inhibit a key inflammatory signaling pathway, offering enhanced therapeutic potential over traditional curcumin. The technology provides improved bioactive compounds for nutraceutical and pharmaceutical...

Published: 12/9/2025 | Inventor(s):

Keywords(s):

Category(s): Natural Products, Research Tools, Therapeutics

Genetic engineering approach for enhancing recombinant protein production by mammalian cells

Summary Vanderbilt researchers have developed a novel approach to enhance recombinant protein production in mammalian cell culture systems through metabolic engineering. By overexpressing specific metabolic proteins in these cells, this technology achieves higher monoclonal antibody titers and increased cell-specific productivity compared to conventional...

Published: 12/9/2025 | Inventor(s):

Keywords(s):

Category(s): Biomanufacturing, Research Tools, Therapeutics

Oxygen-Tolerant Probiotic Therapy for Intestinal Inflammatory Diseases

Summary Anaerobic bacteria used in current probiotic compositions cannot tolerate the oxygen stress found in the gut during inflammation, reducing their effectiveness in restoring a healthy gut microbiome. Vanderbilt researchers have engineered Bacteroides thetaiotaomicron, an obligate anaerobe, to endure oxygen-rich conditions in the gut. This advancement...

Published: 12/2/2025 | Inventor(s):

Keywords(s):

Category(s): Research Tools, Therapeutics

Novel Growth Factor for Liver Regeneration

Summary Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadly implementing this approach. Vanderbilt University researchers have identified a growth factor that promotes...

Published: 5/7/2025 | Inventor(s):

Keywords(s):

Category(s): Research Tools, Therapeutics

Genetically Modified Cell Line for Enhanced Viral Vector Manufacturing

Summary Recent FDA approvals have spurred the demand for viral vector products, prompting the need for more efficient bioproduction methods. In this context, Vanderbilt researchers have engineered a new cell line with significantly enhanced viral production capabilities compared to traditional cell lines. This innovation is expected to lead to substantial...

Published: 8/27/2024 | Inventor(s):

Keywords(s):

Category(s): Research Tools, Natural Products

Lickometer: Instrument for measuring rodent drinking behavior

Background Research on rodent drinking behavior has provided insight into drivers of thirst, circadian rhythms, anhedonia, and drug and ethanol consumption. Traditional methods of recording fluid intake involve weighing bottles, which is cumbersome and lacks temporal resolution. In addition, recent designs are limited by the use of infrared photobeam...

Published: 6/14/2024 | Inventor(s):

Keywords(s):

Category(s): Research Tools

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Summary Researchers at Vanderbilt University have generated a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses. Addressed Need In recent years, adoptive...

Published: 1/18/2024 | Inventor(s):

Keywords(s):

Category(s): Therapeutics, Research Tools

Wolbachia genetic tools for population control of harmful insects

Summary Scientists at Vanderbilt University have engineered transgenic methods for controlling harmful insects such as mosquitoes. These tools may be applied to reduce the populations of insects that transmit infectious diseases to humans or are harmful to food crops and livestock. Addressed Need Vector-borne diseases such as Chikungunya, Dengue,...

Published: 2/15/2024 | Inventor(s):

Keywords(s):

Category(s): Agriculture & Environment, Research Tools

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

Summary A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian...

Published: 8/4/2021 | Inventor(s):

Keywords(s):

Category(s): Energy, Research Tools

A Novel Organs-On-Chip Platform

Summary Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both...

Published: 7/3/2025 | Inventor(s):

Keywords(s):

Category(s): Medical Devices, Microfluidics, Research Tools, Diagnostics

1 2 3 4