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Novel Growth Factor for Liver Regeneration

Summary Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadly implementing this approach. Vanderbilt University researchers have identified a growth factor that promotes...

Published: 11/21/2024 | Inventor(s):

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Category(s): Research Tools, Therapeutics

Genetically Modified Cell Line for Enhanced Viral Vector Manufacturing

Summary Recent FDA approvals have spurred the demand for viral vector products, prompting the need for more efficient bioproduction methods. In this context, Vanderbilt researchers have engineered a new cell line with significantly enhanced viral production capabilities compared to traditional cell lines. This innovation is expected to lead to substantial...

Published: 8/27/2024 | Inventor(s):

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Category(s): Research Tools, Natural Products

Lickometer: Instrument for measuring rodent drinking behavior

Background Research on rodent drinking behavior has provided insight into drivers of thirst, circadian rhythms, anhedonia, and drug and ethanol consumption. Traditional methods of recording fluid intake involve weighing bottles, which is cumbersome and lacks temporal resolution. In addition, recent designs are limited by the use of infrared photobeam...

Published: 6/14/2024 | Inventor(s):

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Category(s): Research Tools

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Summary Researchers at Vanderbilt University have generated a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses. Addressed Need In recent years, adoptive...

Published: 1/18/2024 | Inventor(s):

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Category(s): Therapeutics, Research Tools

Wolbachia genetic tools for population control of harmful insects

Summary Scientists at Vanderbilt University have engineered transgenic methods for controlling harmful insects such as mosquitoes. These tools may be applied to reduce the populations of insects that transmit infectious diseases to humans or are harmful to food crops and livestock. Addressed Need Vector-borne diseases such as Chikungunya, Dengue,...

Published: 2/15/2024 | Inventor(s):

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Category(s): Agriculture & Environment, Research Tools

Improved Biomanufacturing Using Biological Clock Control for High Yield/Low Cost Bioproduct

Summary A team of researchers at Vanderbilt University has developed a method of manipulating the circadian clock of cyanobacteria. This biological manipulation is used to increase gene expression in target genes that produce biofuel and high-value bioproducts, such as pharmaceuticals and cosmetics from precursor-expressing genes. Altering the circadian...

Published: 8/4/2021 | Inventor(s):

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Category(s): Energy, Research Tools

A Novel Organs-On-Chip Platform

Summary Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both...

Published: 7/9/2024 | Inventor(s):

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Category(s): Medical Devices, Microfluidics, Research Tools, Diagnostics

Slc5a7 (choline transporter, CHT) BAC Transgenic Mouse

A Bacterial Artificial Chromosome (BAC) containing the mouse Slc5a7 gene was used to make transgenic mice. Mice show elevated choline transporter and acetylcholine levels and increased treadmill endurance. These mice permit the study of elevated presynaptic choline transporter protein in vivo, expressed solely in cholinergic neurons due to the BAC...

Published: 4/18/2016 | Inventor(s):

Keywords(s): Analgesic, Cardiovascular, Inflammatory/Immune, Metabolic Disorders/ Diabetes, Neuroscience/Neurology

Category(s): Research Tools

Scn1a Knockout Mouse Genetic Model of Epilepsy

This is a unique genetically modified strain of mice that models Dravet syndrome, a severe infant-onset epileptic encephalopathy. They are maintained on apure 129S6/SvEvTac genetic background to facilitate genetic studies.References:Miller AR, Hawkins NA, McCollom CE, Kearney JA (2014) Mapping genetic modifiers of survival in a mouse modelof Dravet...

Published: 5/31/2023 | Inventor(s):

Keywords(s): Cardiovascular, Neuroscience/Neurology

Category(s): Research Tools

Immortalized Mouse Epididymal Epithelial Cell Lines

SummaryThese cell lines are useful for studying the regulation of tissue-specific gene expression, and may also be used to identify epididymal-specific transcription factors involved in expression of specific proteins in the epididymis. Four cell lines are available, including PC1 from proximal caput, and the DC1, DC2, and DC3 cell lines from the distal...

Published: 5/31/2023 | Inventor(s): Robert Matusik, Yoshihiko Araki, Masuo Obinata, Kichiya Suzuki, Marie-Claire Orgebin-Crist

Keywords(s): Genitourinary

Category(s): Research Tools

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