http://vanderbilt.technologypublisher.comBe the first to know about the latest inventions and technologies available from Vanderbilt Universityen-USThu, 11 Mar 2010 10:19:26 GMTThu, 18 Feb 2010 07:36:29 GMThttp://blogs.law.harvard.edu/tech/rsslee.bridges@vanderbilt.eduCopyright 2010, Vanderbilt Universityhttp://vanderbilt.technologypublisher.com/technology/4691Vanderbilt Researchers have created a novel nanoparticle and have demonstrated that it can effectively deliver brimonidine, a drug currently used in the treatment of glaucoma, to retina neurons located in the back of the eye of a glaucoma mouse model.InventorsDavid CalkinsEva HarthAlice van der EndeThu, 18 Feb 2010 07:36:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4691http://vanderbilt.technologypublisher.com/technology/4202Vanderbilt researchers have created a high resolution, single nucleotide polymorphism (SNP) meiotic map of the zebrafish model organism, Danio rerio, and characterized diversity of laboratory strains. This resource will allow researchers to rapidly and accurately conduct positional cloning using SNP genotyping platforms.Supplemental DocumentsVU1017--Genetic Mapping Resource for ZebrafishInventorsKevin BradleyJeffrey SmithTue, 24 Nov 2009 12:26:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4202http://vanderbilt.technologypublisher.com/technology/4201Under the direction of Kevin Niswender, M.D., Ph.D. and David Weaver, Ph.D., Vanderbilt is seeking a partner for an early stage drug discovery program aimed at identifying activators of the glucagon-like peptide-1 (GLP-1) receptor. An initial screen of 160,000 compounds is complete, and several interesting molecules were identified. Next steps include selecting promising compounds for further investigation, developing structure activity libraries around those compounds, assessing off target activity, optimizing for DMPK and testing in in-vitro and in-vivo models.Supplemental DocumentsVU0636--Q...Tue, 24 Nov 2009 12:26:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4201http://vanderbilt.technologypublisher.com/technology/4200The recently announced introduction of a new oral formulation combining aspirin and a gastro-protective agent acknowledges the need for a safer, better-tolerated anti-platelet agent, an endorsement for gastric-sparing transdermal aspirin.Supplemental DocumentsVU9117--Percutaneous Aspirin as an Antithrombotic AgentInventorsDesmond FitzgeraldRudolph KeimowitzTue, 24 Nov 2009 12:26:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4200http://vanderbilt.technologypublisher.com/technology/4198This technology, developed at Vanderbilt University’s Institute for Software Integrated Systems, uses radio interferometry and attains, simultaneously, a high degree of accuracy, considerably longer range and lower cost than other technologies. Supplemental DocumentsVU0569--Highly Accurate Radio Chip Localization TechnologyInventorsSebestyen DoraBranislav KusyAkos LedecziMiklos MarotiKaroly MolnarAndras NadasPeter VolgyesiTue, 24 Nov 2009 12:24:53 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4198http://vanderbilt.technologypublisher.com/technology/3066InventorsMichael AllesMon, 22 Jun 2009 08:21:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/3066http://vanderbilt.technologypublisher.com/technology/2772Vanderbilt researchers have developed a unique system for patterning cells or proteins in cell culture environments using magnetically attachable stencils (MAtS) secured onto a culture surface by applying transbase magnets.Supplemental DocumentsVU0977--Magnetically Attachable Polydimethylsiloxane Stencils (MAtS)InventorsWilliam AshbyPhilip SamsonJohn Wikswo, Jr.Andries ZijlstraWed, 17 Jun 2009 11:27:55 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2772http://vanderbilt.technologypublisher.com/technology/2771Currently Vanderbilt researchers are focusing on the development of a system suitable for powering capsule endoscopes through the human GI tract.Supplemental DocumentsVU0987--A Fluid-Power System for Tetherless Medical DevicesInventorsRyan FarrisJenna ToenniesRobert WebsterWed, 17 Jun 2009 11:27:55 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2771http://vanderbilt.technologypublisher.com/technology/2770The Marnett Laboratory at Vanderbilt University has synthesized and validated in vivo COX-2 targeted imaging agents and therapeutics. Since COX-2 is expressed at high levels in many solid tumors but not in surrounding normal tissues, this new class of compounds offers a strategy for directing imaging or therapeutic agents selectively to tumors. The laboratory has also designed a novel class of non-steroidal anti-infl ammatory drug (NSAID) derivatives that lack COX inhibitory activity but activate other molecular targets.Supplemental DocumentsVU0694--Manipulating COX Enzymes - Novel Diagnostic ...Wed, 17 Jun 2009 11:27:54 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2770http://vanderbilt.technologypublisher.com/technology/2731A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy).InventorsVenkata KodavaliPat LevittKaroly MirnicsVishwajit NimgaonkarFri, 12 Jun 2009 08:05:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2731http://vanderbilt.technologypublisher.com/technology/2661Vanderbilt inventors propose an inexpensive and easy to manufacture hydraulic accumulator. The proposed hydraulic accumulator technology is intended for energy storage. It is superior to current alternatives in that it provides a simple, efficient and relatively cheap method for storing a large amount of energy in a relatively small volume and mass. One example of its application would be in regenerative braking of passenger vehicles (hydraulic hybrid).Supplemental DocumentsVU09108--High Energy-Density Hydraulic AccumulatorInventorsEric BarthKarl BrandtAlexander PedchenkoOliver TanMon, 01 Jun 2009 15:45:52 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2661http://vanderbilt.technologypublisher.com/technology/2660Vanderbilt inventors propose a free piston system that provides high inertance and tunable dynamics.Supplemental DocumentsVU09107--High Inertia, Low Mass Free PistonInventorsEric BarthJoel WillhiteMon, 01 Jun 2009 15:45:52 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2660http://vanderbilt.technologypublisher.com/technology/2299Vanderbilt inventors have developed a new class of liquid crystals with high dielectric anisotropy.Supplemental DocumentsVU0999--Polar Liquid Crystals with High Dielectric AnisotropyInventorsPiotr KaszynskiBryan RingstrandTue, 12 May 2009 08:47:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2299http://vanderbilt.technologypublisher.com/technology/2094This technology eliminates the need to place cortical fiducial markers during image guided neurosurgery. As an additional and important feature, the technology is able to compensate for brain shift due to deformation of the brain during surgery.Supplemental DocumentsVU0506--Brain Shift Compensation AlgorithmInventorsRichard Chun-ChengPrashanth DumpuriDoug HackworthMichael MigaTue, 14 Apr 2009 14:38:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2094http://vanderbilt.technologypublisher.com/technology/2093The present invention is a method for assessing capillary permeability to determine vascular lung injury without requiring the injection of radioactive material or requiring the sampling of blood. The method includes measuring impedance and ultrasonic velocity of blood flow through a lung. A hypertonic bolus is injected into the blood flow, and measurements of the blood flow are taken to determine the ultrasonic velocity and the electrical impedance of the blood. These measurements are used to calculate the capillary transport quantity, which is the product of the reflection coefficient for mo...Tue, 14 Apr 2009 10:25:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2093http://vanderbilt.technologypublisher.com/technology/2089This invention relates to fatty acid 13-hydroperoxide lyase protein from guava (Psidium guajava) and the gene encoding the protein. Expression systems for recombinant guava 13-hydroperoxide lyase and methods of using recombinant guava 13-hydroperoxide lyase for the production of green notes are provided.InventorsAlan BrashNathalie TijetTue, 14 Apr 2009 10:25:44 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2089http://vanderbilt.technologypublisher.com/technology/2088Isolated and purified proteins and nucleic acids including a novel member of the immunoglobulin super-family characterized as having SHP-2 binding activity and cell signaling activity and called protein zero related or PZR, and cDNA encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to PZR, and methods of producing the same, are also disclosed. PZR is characterized as having SHP-2 binding activity and cell signaling activity and thus, therapeutic methods involvi...Tue, 14 Apr 2009 10:25:43 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2088http://vanderbilt.technologypublisher.com/technology/2087This invention is directed to cloning and characterization of BVES (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick, mouse and human. Also provided are applications of BVES as a marker for cardiovascular or skeletal muscle diseases.WebsiteFor more information about Cloning and Characterization of BVESInventorsDavid BaderDavid ReeseTue, 14 Apr 2009 10:25:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2087http://vanderbilt.technologypublisher.com/technology/2086InventorsAlan BrashTue, 14 Apr 2009 10:25:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2086http://vanderbilt.technologypublisher.com/technology/2084Dr. Liang has identified a new protein (termed “Killin”) that represents a novel protein for cancer diagnosis, treatment and drug screening. Killin is a small (178 amino acids) nuclear DNA binding protein shown to play a role in cell cycle control. Supplemental DocumentsVU0643--The Tumor Suppressor KillinInventorsYong-jig ChoPeng LiangTue, 14 Apr 2009 10:25:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2084http://vanderbilt.technologypublisher.com/technology/2083This technology provides a method for analyzing tissue from the surgical margin of resected tumor, and the use of such information to predict recurrence, survival, and treatment efficacy in cancer patients.InventorsRichard CaprioliTue, 14 Apr 2009 10:25:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2083http://vanderbilt.technologypublisher.com/technology/2082This technology provides for the simultaneous assessment of multiple tissue regions or microregions, the benefit being homogeneity of the sampling, both in terms of tissue content and timing. Discrete regions of a tissue sample, such as those demarcated by microwells formed within the tissue itself or tissue plugs removed from the tissue in a spatially referenced fashion, can be treated with one or more physical or chemical treatments to liberate target molecules of interest. Subsequent analysis of said target molecules by, e.g., mass spectroscopy, permits identification of a variety of biolog...Tue, 14 Apr 2009 10:25:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2082http://vanderbilt.technologypublisher.com/technology/2081Currently methodologies exists using MALDI mass spectrometry to image proteins within tissue sections. These methodologies have several limitations, such that only soluble, highly abundant proteins are detected. Further, due to the sensitivity of time of flight mass spectrometry, higher molecular weight proteins are not visualized well. This technology addresses these limitations and allows the detection of proteins currently not detected by MALDI matrix detection methods. Thus, insoluble and low abundant proteins could be readily detected. In addition, because this technology uses a matrix fr...Tue, 14 Apr 2009 10:25:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2081http://vanderbilt.technologypublisher.com/technology/2080This technology provides for a proteomic approach to grading gliomas, and for predicting patient survival. In addition to employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose expression is altered in various gliomas can be used to predict the stage/classification of a glioma, as well as to indicate whether a given patient will be a short- or long-term survivor.InventorsRichard CaprioliTue, 14 Apr 2009 10:25:36 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2080http://vanderbilt.technologypublisher.com/technology/2078The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.InventorsAlfred GeorgeDao WangTue, 14 Apr 2009 10:25:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2078