http://vanderbilt.technologypublisher.comBe the first to know about the latest inventions and technologies available from Vanderbilt Universityen-USThu, 29 Jul 2010 13:16:16 GMTFri, 21 May 2010 14:26:06 GMThttp://blogs.law.harvard.edu/tech/rsslee.bridges@vanderbilt.eduCopyright 2010, Vanderbilt Universityhttp://vanderbilt.technologypublisher.com/technology/5261This technology represents a new advance towards easily and rapidly producing a vaccine for influenza. Specifically, a method for the production of the recombinant viral glycoprotein avian influenza H5N1 hemagglutinin has been created that can be used as a vaccine for avian flu. A modified version of the HA gene from the influenza virus H5N1 has been expressed to high levels in mammalian cell culture. This HA gene is optimized for expression in mammalian cells and can produce milligram quantities of H5 HA protein with native conformation and immunogenic properties.Supplemental Documents...Fri, 21 May 2010 14:26:06 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/5261http://vanderbilt.technologypublisher.com/technology/5255Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.Supplemental DocumentsVU08133--Novel PLD Inhibitors as a Cancer TherapyInventorsH. Alex BrownCraig LindsleySarah ScottAlex WatersonFri, 21 May 2010 08:41:05 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/5255http://vanderbilt.technologypublisher.com/technology/4691Vanderbilt researchers have created a novel nanoparticle that can be loaded with 2-8 times more drug than current delivery systems with a tailored linear release rate. They have demonstrated the power of this nanoparticle by effectively delivering the drug brimonidine, currently used in the treatment of glaucoma, to the retina at the back of the eye.Supplemental DocumentsVU08127--Multifunctionalized Nanoparticles as a Delivery SystemInventorsDavid CalkinsEva HarthAlice van der EndeThu, 18 Feb 2010 07:36:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4691http://vanderbilt.technologypublisher.com/technology/4202Vanderbilt researchers have created a high resolution, single nucleotide polymorphism (SNP) meiotic map of the zebrafish model organism, Danio rerio, and characterized diversity of laboratory strains. This resource will allow researchers to rapidly and accurately conduct positional cloning using SNP genotyping platforms.Supplemental DocumentsVU1017--Genetic Mapping Resource for ZebrafishInventorsKevin BradleyJeffrey SmithTue, 24 Nov 2009 12:26:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4202http://vanderbilt.technologypublisher.com/technology/4201InventorsMichael Bowers IIJames McBrideSandra RosenthalTue, 24 Nov 2009 12:26:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4201http://vanderbilt.technologypublisher.com/technology/4200The recently announced introduction of a new oral formulation combining aspirin and a gastro-protective agent acknowledges the need for a safer, better-tolerated anti-platelet agent, an endorsement for gastric-sparing transdermal aspirin.Supplemental DocumentsVU9117--Percutaneous Aspirin as an Antithrombotic AgentInventorsDesmond FitzgeraldRudolph KeimowitzTue, 24 Nov 2009 12:26:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4200http://vanderbilt.technologypublisher.com/technology/4198This technology, developed at Vanderbilt University’s Institute for Software Integrated Systems, uses radio interferometry and attains, simultaneously, a high degree of accuracy, considerably longer range and lower cost than other technologies. Supplemental DocumentsVU0569--Highly Accurate Radio Chip Localization TechnologyInventorsSebestyen DoraBranislav KusyAkos LedecziMiklos MarotiKaroly MolnarAndras NadasPeter VolgyesiTue, 24 Nov 2009 12:24:53 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/4198http://vanderbilt.technologypublisher.com/technology/3066InventorsMichael AllesMon, 22 Jun 2009 08:21:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/3066http://vanderbilt.technologypublisher.com/technology/2772Vanderbilt researchers have developed a unique system for patterning cells or proteins in cell culture environments using magnetically attachable stencils (MAtS) secured onto a culture surface by applying transbase magnets.Supplemental DocumentsVU0977--Magnetically Attachable Polydimethylsiloxane Stencils (MAtS)InventorsWilliam AshbyPhilip SamsonJohn Wikswo, Jr.Andries ZijlstraWed, 17 Jun 2009 11:27:55 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2772http://vanderbilt.technologypublisher.com/technology/2771Currently Vanderbilt researchers are focusing on the development of a system suitable for powering capsule endoscopes through the human GI tract.Supplemental DocumentsVU0987--A Fluid-Power System for Tetherless Medical DevicesInventorsRyan FarrisJenna ToenniesRobert WebsterWed, 17 Jun 2009 11:27:55 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2771http://vanderbilt.technologypublisher.com/technology/2770The Marnett Laboratory at Vanderbilt University has synthesized and validated in vivo COX-2 targeted imaging agents and therapeutics. Since COX-2 is expressed at high levels in many solid tumors but not in surrounding normal tissues, this new class of compounds offers a strategy for directing imaging or therapeutic agents selectively to tumors. The laboratory has also designed a novel class of non-steroidal anti-infl ammatory drug (NSAID) derivatives that lack COX inhibitory activity but activate other molecular targets.Supplemental DocumentsVU0694--Manipulating COX Enzymes - Novel Diagnostic ...Wed, 17 Jun 2009 11:27:54 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2770http://vanderbilt.technologypublisher.com/technology/2731A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy).InventorsVenkata KodavaliPat LevittKaroly MirnicsVishwajit NimgaonkarFri, 12 Jun 2009 08:05:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2731http://vanderbilt.technologypublisher.com/technology/2661Vanderbilt inventors propose an inexpensive and easy to manufacture hydraulic accumulator. The proposed hydraulic accumulator technology is intended for energy storage. It is superior to current alternatives in that it provides a simple, efficient and relatively cheap method for storing a large amount of energy in a relatively small volume and mass. One example of its application would be in regenerative braking of passenger vehicles (hydraulic hybrid).Supplemental DocumentsVU09108--High Energy-Density Hydraulic AccumulatorInventorsEric BarthKarl BrandtAlexander PedchenkoOliver TanMon, 01 Jun 2009 15:45:52 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2661http://vanderbilt.technologypublisher.com/technology/2660Vanderbilt inventors propose a free piston system that provides high inertance and tunable dynamics.Supplemental DocumentsVU09107--High Inertia, Low Mass Free PistonInventorsEric BarthJoel WillhiteMon, 01 Jun 2009 15:45:52 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2660http://vanderbilt.technologypublisher.com/technology/2299Vanderbilt inventors have developed a new class of liquid crystals with high dielectric anisotropy.Supplemental DocumentsVU0999--Polar Liquid Crystals with High Dielectric AnisotropyInventorsPiotr KaszynskiBryan RingstrandTue, 12 May 2009 08:47:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2299http://vanderbilt.technologypublisher.com/technology/2094This technology eliminates the need to place cortical fiducial markers during image guided neurosurgery. As an additional and important feature, the technology is able to compensate for brain shift due to deformation of the brain during surgery.Supplemental DocumentsVU0506--Brain Shift Compensation AlgorithmInventorsRichard Chun-ChengPrashanth DumpuriDoug HackworthMichael MigaTue, 14 Apr 2009 14:38:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2094http://vanderbilt.technologypublisher.com/technology/2093The present invention is a method for assessing capillary permeability to determine vascular lung injury without requiring the injection of radioactive material or requiring the sampling of blood. The method includes measuring impedance and ultrasonic velocity of blood flow through a lung. A hypertonic bolus is injected into the blood flow, and measurements of the blood flow are taken to determine the ultrasonic velocity and the electrical impedance of the blood. These measurements are used to calculate the capillary transport quantity, which is the product of the reflection coefficient for mo...Tue, 14 Apr 2009 10:25:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2093http://vanderbilt.technologypublisher.com/technology/2089This invention relates to fatty acid 13-hydroperoxide lyase protein from guava (Psidium guajava) and the gene encoding the protein. Expression systems for recombinant guava 13-hydroperoxide lyase and methods of using recombinant guava 13-hydroperoxide lyase for the production of green notes are provided.InventorsAlan BrashNathalie TijetTue, 14 Apr 2009 10:25:44 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2089http://vanderbilt.technologypublisher.com/technology/2088Isolated and purified proteins and nucleic acids including a novel member of the immunoglobulin super-family characterized as having SHP-2 binding activity and cell signaling activity and called protein zero related or PZR, and cDNA encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to PZR, and methods of producing the same, are also disclosed. PZR is characterized as having SHP-2 binding activity and cell signaling activity and thus, therapeutic methods involvi...Tue, 14 Apr 2009 10:25:43 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2088http://vanderbilt.technologypublisher.com/technology/2087This invention is directed to cloning and characterization of BVES (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick, mouse and human. Also provided are applications of BVES as a marker for cardiovascular or skeletal muscle diseases.WebsiteFor more information about Cloning and Characterization of BVESInventorsDavid BaderDavid ReeseTue, 14 Apr 2009 10:25:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2087http://vanderbilt.technologypublisher.com/technology/2086InventorsAlan BrashTue, 14 Apr 2009 10:25:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2086http://vanderbilt.technologypublisher.com/technology/2084Dr. Liang has identified a new protein (termed “Killin”) that represents a novel protein for cancer diagnosis, treatment and drug screening. Killin is a small (178 amino acids) nuclear DNA binding protein shown to play a role in cell cycle control. Supplemental DocumentsVU0643--The Tumor Suppressor KillinInventorsYong-jig ChoPeng LiangTue, 14 Apr 2009 10:25:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2084http://vanderbilt.technologypublisher.com/technology/2083This technology provides a method for analyzing tissue from the surgical margin of resected tumor, and the use of such information to predict recurrence, survival, and treatment efficacy in cancer patients.InventorsRichard CaprioliTue, 14 Apr 2009 10:25:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2083http://vanderbilt.technologypublisher.com/technology/2082This technology provides for the simultaneous assessment of multiple tissue regions or microregions, the benefit being homogeneity of the sampling, both in terms of tissue content and timing. Discrete regions of a tissue sample, such as those demarcated by microwells formed within the tissue itself or tissue plugs removed from the tissue in a spatially referenced fashion, can be treated with one or more physical or chemical treatments to liberate target molecules of interest. Subsequent analysis of said target molecules by, e.g., mass spectroscopy, permits identification of a variety of biolog...Tue, 14 Apr 2009 10:25:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2082http://vanderbilt.technologypublisher.com/technology/2081Currently methodologies exists using MALDI mass spectrometry to image proteins within tissue sections. These methodologies have several limitations, such that only soluble, highly abundant proteins are detected. Further, due to the sensitivity of time of flight mass spectrometry, higher molecular weight proteins are not visualized well. This technology addresses these limitations and allows the detection of proteins currently not detected by MALDI matrix detection methods. Thus, insoluble and low abundant proteins could be readily detected. In addition, because this technology uses a matrix fr...Tue, 14 Apr 2009 10:25:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2081http://vanderbilt.technologypublisher.com/technology/2080This technology provides for a proteomic approach to grading gliomas, and for predicting patient survival. In addition to employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose expression is altered in various gliomas can be used to predict the stage/classification of a glioma, as well as to indicate whether a given patient will be a short- or long-term survivor.InventorsRichard CaprioliTue, 14 Apr 2009 10:25:36 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2080http://vanderbilt.technologypublisher.com/technology/2078The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.InventorsAlfred GeorgeDao WangTue, 14 Apr 2009 10:25:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2078http://vanderbilt.technologypublisher.com/technology/2076The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn's disease or ulcerative colitis) in a subject, such as a human patient.InventorsBrent PolkFang YanTue, 14 Apr 2009 10:25:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2076http://vanderbilt.technologypublisher.com/technology/2013Vanderbilt researchers and clinicians have developed a database and web application that tracks unborn fetuses as a separate patient population. Traditionally unborn fetuses are monitored and tracked for abnormalities and all of their information and documentation is placed within the mother’s medical chart. This program creates a separate medical file for the unborn fetus that is linked to the maternal medical file. This system allows clinicians to easily sort and track unborn fetus abnormalities and easily identify treatment options that have shown to be beneficial to that patient populat...Fri, 10 Apr 2009 08:08:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2013http://vanderbilt.technologypublisher.com/technology/2012Vanderbilt researchers have developed a device that allows for a more accurate and precise detection of brain tumor borders in real time. This allows neurosurgeons to remove all tumor tissue without removing critical normal tissue in surgical brain resections. Supplemental DocumentsVU9978--Real Time Surgical ImagingInventorsEric JansenWei-Chiang LinAnita Mahadevan-JansenMassoud MotamediSteven TomsFri, 10 Apr 2009 08:08:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2012http://vanderbilt.technologypublisher.com/technology/2011The present system developed by Vanderbilt researchers provides a combination of a base laser pump connected to a laser surgical probe via a connection assembly. The surgical probe has a disposable tip wherein the Er:YAG lasing occurs. This system is useful in laser surgeries involving high precision and appropriate power levels. In particular, intraocular surgeries could benefit from the use of such a system.Supplemental DocumentsVU9738--Micro Erbium-YAG LaserInventorsDerek AbbottKaren JoosJin ShenFri, 10 Apr 2009 08:08:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2011http://vanderbilt.technologypublisher.com/technology/2010This software includes IDL codes for hepatic vessel enhancement, skeletonization and segmentation. It does not have a user’s manual and no friendly user’s interface. It is a series of functions and programs. Fully functional and tested on a limited number of images by the implementer. This software may facilitate the segmentation of the hepatic vasculature, which is critical for the development of computer-assisted surgical systems for liver surgery.InventorsBenoit DawantQingyang ShangFri, 10 Apr 2009 08:08:50 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2010http://vanderbilt.technologypublisher.com/technology/2009Robust and accurate sensor fusion algorithm using time of arrival data for acoustic event localization. The fusion algorithm compensates for incorrect measurements including multipath effects. The algorithm is capable of localizing multiple simultaneous sources with a high degree of accuracy.InventorsGyorgy BaloghAkos LedecziMiklos MarotiGyula SimonFri, 10 Apr 2009 08:08:50 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2009http://vanderbilt.technologypublisher.com/technology/2007Fri, 10 Apr 2009 08:08:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2007http://vanderbilt.technologypublisher.com/technology/2005Vanderbilt researchers have identified compounds that selectively differentiate stem cells into cardiomyocytes by perturbing key pathways. Medicinal chemistry is currently underway to develop lead compounds that maybe used for the treatment of damaged cardiac muscle.InventorsJijun HaoAntonis HatzopoulosCharles HongCorey HopkinsCraig LindsleyFri, 10 Apr 2009 08:08:47 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2005http://vanderbilt.technologypublisher.com/technology/2003Supplemental DocumentsSpermidinyl-CoA-based HAT inhibitors...InventorsKeya BandyopadhyayRuth Anne GjersetJoseph ParelloFri, 10 Apr 2009 08:08:45 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2003http://vanderbilt.technologypublisher.com/technology/2002InventorsDavid ZealearFri, 10 Apr 2009 08:08:45 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/2002http://vanderbilt.technologypublisher.com/technology/1810The Conflict of Interest Disclosure System ("CIDS") has been designed for use by universities, particularly those that conduct considerable academic research. CIDS provides an interface that permits faculty and staff to complete their conflict of interest disclosure on-line. It also permits the conflict of interest administrator to assign those who are responsible for approving conflict of interest disclosures and allows those approvers to review, return and/or approve an assigned employee’s disclosure. CIDS provides recommended action plans for those reporting conflicts and an automated email...Tue, 24 Mar 2009 10:23:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1810http://vanderbilt.technologypublisher.com/technology/1806The OLINDA/EXM® personal computer code performs dose calculations and kinetic modeling for radiopharmaceuticals (OLINDA/EXM stands for Organ Level INternal Dose Assessment/EXponential Modeling). OLINDA® calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on user-supplied biokinetic data to support such calculations for nuclear medicine drugs. These calculations are used to perform risk/benefit evaluations of the use of such pharmaceuticals in diagnostic and therapeutic applications in nuclear medicine...Tue, 24 Mar 2009 10:23:12 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1806http://vanderbilt.technologypublisher.com/technology/1804The invention relates to the analysis of blood analytes using a device inserted into the bloodstream. This device comprises a housing suitable for disposition in a subject's bloodstream, a probe comprising a support coupled to the housing, and a binding agent coupled to the support. The housing can be a hypodermic needle or syringe or a catheter. The probe of the device may contain a support coupled to the housing such as a stent, a filter, a chip or a membrane, or the support may be a polymer, a resin, glass, or a porous material. The probe may comprise a support and binding agent and may be ...Tue, 24 Mar 2009 10:23:05 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1804http://vanderbilt.technologypublisher.com/technology/1803The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle voltage-gated sodium channel (hSkMl). The cells enable high throughput screening of compounds that modulate sodium channel activity.InventorsAlfred GeorgeTue, 24 Mar 2009 10:23:03 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1803http://vanderbilt.technologypublisher.com/technology/1802The mutation allows for the first genetic test to be conducted for one form of chronic fatigue or mitral valve prolapse which we describe as orthostatic intolerance or postural tachycardia syndrome (POTS). The technology allows for the development of this test and the development of other tests in the same gene at other loci that may contribute to similar illnesses. The awareness of a phenotype associated with the mutation in the antidepressant-sensitive NET allows for evaluation of the role of the NET gene in mental illness and thus the development of genetic tests for increased susceptibilit...Tue, 24 Mar 2009 10:23:00 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1802http://vanderbilt.technologypublisher.com/technology/1800InventorsAlfred GeorgeYing JinTerri NiTue, 24 Mar 2009 10:22:45 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1800http://vanderbilt.technologypublisher.com/technology/1796A method and/or device using Second Harmonic Generation for determining first and second band offsets at a semiconductor/dielectric heterointerface, which includes the semiconductor/dielectric heterointerface exposed to incident photons from a light source, a detector for generating a signal by detecting emitted photons from the semiconductor/dielectric heterointerface and an element for changing the energy of incident photons to monitor the first and second band offsets. InventorsGunter LuepkeNorman TolkWei WangMon, 23 Mar 2009 14:02:27 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1796http://vanderbilt.technologypublisher.com/technology/1795An A-mode ultrasound transducer is tracked in three-dimensions by an optical position tracking system as the transducer is scanned over the skin to generate measurements of bone surface distance from the transducer. A processor correlates the ultrasound data with position and orientation data to generate a three-dimensional physical space model of the bone surface which is registered with an image space model of the bone surface generated from a tomographic image to produce an alignment of the two models. The ultrasound transducer is replaced by an instrument which is also optically tracked. T...Mon, 23 Mar 2009 14:02:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1795http://vanderbilt.technologypublisher.com/technology/1794A closed-loop, feedback-controlled direct laser fabrication system is disclosed. The feedback refers to the actual growth conditions obtained by real-time analysis of thermal radiation images. The resulting system can fabricate components with several fold improvement in dimensional tolerances and surface finish. InventorsMichelle GriffithWilliam HofmeisterGerald KnorovskyDanny MacCallumM. Eric SchliengerJohn SmugersekyMon, 23 Mar 2009 14:02:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1794http://vanderbilt.technologypublisher.com/technology/1793The invention relates to a system and method for on-line coupling of liquid capillary separation with matrix-assisted laser desorption ionization mass spectrometric analysis. In this system and method, analyte from liquid capillary separation is mixed with matrix molecules for matrix-assisted laser desorption ionization. Continuous flow of the analyte/matrix combined with vacuum conditions allows evaporation and crystallization of homogeneous samples on a solid sample surface. Dual use of laser irradiation to desorb/ionize and remove excess sample facilitates on-line use and automation. Invent...Mon, 23 Mar 2009 14:02:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1793http://vanderbilt.technologypublisher.com/technology/1791This application describes the design of the split-tube flexure, a unique precision revolute joint that exhibits a considerably larger range of motion and significantly better multi-axis revolute joint characteristics than a conventional flexure. The development of this joint enables the implementation of spatially-loaded revolute joint-based precision machines with well-behaved kinematic and dynamic characteristics and without the backlash and stick-slip behavior that would otherwise prevent precision machine control.InventorsMichael GoldfarbJohn SpeichMon, 23 Mar 2009 14:02:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1791http://vanderbilt.technologypublisher.com/technology/1790Catalyst for direct methanol fuel cells: The invention relates to methods for preparing polymetallic precursors and for preparing improved nanocomposites formed from such precursors which are useful in fuel cell catalyst compositions. The nanocomposites include a support and a plurality of polymetallic nanoparticles with a selected metal atomic ratio. Crystalline intermetallic or metal alloy nanoparticles form when a polymetallic precursor having a particular metal stoichiometry is contacted with a conductive support, and the precursor is thermally degraded on the support leading to retention ...Mon, 23 Mar 2009 14:02:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1790http://vanderbilt.technologypublisher.com/technology/1789This technology is a diamond triode for micro and power electronics. Diamond microtip field emitters are used in triode vacuum electronic devices, sensors and displays. Diamond triode devices having integral anode and grid structures are fabricated using a patented process. Ultra-sharp tips are formed on the emitters in the fabrication process in which diamond is deposited into mold cavities in a two-step deposition sequence. During deposition of the diamond, the carbon graphite content is carefully controlled to enhance emission performance. The tips or the emitters are treated by post-fabric...Mon, 23 Mar 2009 14:02:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1789http://vanderbilt.technologypublisher.com/technology/1788A microcatheter with a deployable parachute attached to its distal tip: The parachute in its retracted position lies flush against the exterior wall of the distal segment of the catheter. Control strings, cables or wires traverse the length of the microcatheter through channels within its wall and exit through strategically placed apertures at the tip of the microcatheter to attach to the parachute. When the parachute is deployed, the microcatheter is guided by blood flow or jets of liquid that are injected through the microcatheter. When the parachute is retracted, the microcatheter may be us...Mon, 23 Mar 2009 14:02:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1788http://vanderbilt.technologypublisher.com/technology/1787A nutation motion generator which transforms linear motion into nutation motion. The device employs a spherical, four-bar linkage mechanism. Three four-bar linkage mechanisms are sandwiched between a stationary support surface and a drive plate and arranged at 120-degree intervals about the support surface. Each four-bar linkage mechanism is constructed of four planar sections which are hinged along their edges, the four hinged planar sections being essentially triangular in shape so that they would join at a point in the center of the device if they extended to the apex of their respective tr...Mon, 23 Mar 2009 14:02:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1787http://vanderbilt.technologypublisher.com/technology/1785Measurements are made and processed to determine the basic electrical rhythm (BER) frequency at various locations along the intestinal tract. A nominal value for the BER frequency is established at each location, and is used as a diagnostic tool to assess the health of the intestinal. Ischemia is the initial diagnostic application. InventorsLeonard BradshawJavad GolzarianAndrei IrimiaWilliam RichardsDaniel StatonJohn Wikswo, Jr.Mon, 23 Mar 2009 14:02:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1785http://vanderbilt.technologypublisher.com/technology/1784This laser surgery method provides for efficient ablation of tissue with little or no thermal damage to adjacent tissue. This is achieved by tuning the laser wavelength to the absorption peak of the proteinaceous material or functional groups in them, e.g., amides. The power level of the laser can be selected to either vaporize or liquefy the targeted tissue. InventorsMichael CopelandGlenn EdwardsRegan LoganDenis O'DayMon, 23 Mar 2009 14:02:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1784http://vanderbilt.technologypublisher.com/technology/1783This invention is a magnetometer that has intersecting supports at right angles to each other. A planar sensor/detector array is mounted on each support surface. Each array includes at least two pairs of magnetic filed sensors and associated SQUID detectors. The sensors are placed parallel to the line of intersection of the two supports. This magnetometer can measure components and spatial variation of the magnetic field on a surface of interest. The device provides for resolution of the magnetic field vectors parallel to and normal to the surface of interest. InventorsWilliam BlackEugene Hirs...Mon, 23 Mar 2009 14:02:22 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1783http://vanderbilt.technologypublisher.com/technology/1782An optimization method is used in a real-time diagnostic system that monitors alarm sources and detects possible sources of failure in an industrial process. When the diagnostic system detects one or more alarms, it determines which components are likely sources of failure. The system determines the level of criticality of certain other, currently off-line, alarms sources and schedules the off-line alarms for evaluation according to their levels of criticality. The system refines its analysis of likely sources of failure by evaluating the status of the previously off-line alarm sources Those p...Mon, 23 Mar 2009 14:02:22 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1782http://vanderbilt.technologypublisher.com/technology/1781The invention is a dexterous surgical manipulator. The device provides a surgical "hand" similar in concept to those used by Intuitive Surgical's Da Vinci robotic system. This system differs from the Intuitive system because it is mechanically operated with no robotic interface or assistance. The system provides 7 degrees of freedom and uses an interface which maps motions of the surgeon's input to the tool's "hands". This provides the operator with an intuitive interface without the need for computer intervention. In this regard the tool's interface is novel. Supplemental DocumentsVU0913--Dex...Mon, 23 Mar 2009 14:02:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1781http://vanderbilt.technologypublisher.com/technology/1780This new tracheostomy tube design prevents the need for decannulation when changing from a cuffed to cuffless (or vice versa) tracheostomy. It also enables a comfortable and fit in patients with both large and small neck diameters. The tube enhances patient safety by maintaining the airway at all times when downsizing or upsizing.Supplemental DocumentsVU0910--Cuffed Inner Cannula and Flexible Outer Cannula Tracheostomy TubeInventorsSanjay AthavaleTodd DuttonRobert WebsterMon, 23 Mar 2009 14:02:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1780http://vanderbilt.technologypublisher.com/technology/1779The porous silicon membrane waveguide is a low-cost, high sensitivity sensor for the detection of biological and chemical materials. It is cheaper and more sensitive than commercial fiber optic and SPR sensors for low molecular weight species.InventorsRaymond MernaughGuoguang RongSharon WeissMon, 23 Mar 2009 14:02:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1779http://vanderbilt.technologypublisher.com/technology/1778Optical beam choppers have numerous applications and are ubiquitous in scientific and industrial equipment. The present technology improves the state-of-the-art for modulation and lock-in amplifi cation using mechanical beam choppers. The system achieves world class performance with lower limits of detection, decreased need for mechanical precision and decreased cost. Because of the high performance and low cost, the system may replace existing technology in current applications, and it may also enable the development of new products that are not currently feasible or economical with current t...Mon, 23 Mar 2009 14:02:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1778http://vanderbilt.technologypublisher.com/technology/1777New tool for insertion of stapes prosthesis. Holds prosthesis at user defined angle and has one-touch deployment. Advantage over current standard which is to use a surgical alligator (micrograpper). Allows easier insertion of stapes prosthesis by (1) single touch deployment, (2) 2-d site of contact between instrument and prosthesis (current standard in 1-D), and (3) customization by user via bending of device.InventorsRobert LabadieJason MitchellMon, 23 Mar 2009 14:02:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1777http://vanderbilt.technologypublisher.com/technology/1776This is a high resolution imaging device that can detect the fundamental functional units of cortical organization. Currently, with existing technology, we are able to monitor the activity of these units in the awake, head-fixed animal using large standard sized cameras mounted on heavy camera arms. However, we need a capability to conduct such monitoring in the awake and freely moving animal so that we can relate specific patterns of cortical activity to natural behaviors.InventorsBenoit DawantJack NobleMon, 23 Mar 2009 14:02:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1776http://vanderbilt.technologypublisher.com/technology/1774Vanderbilt researchers have designed several variants of sub-millimeter probes for application with OCT systems. These probes permit diagnosis, therapy delivery and sampling using minimally invasive techniques. In addition, they permit the combination of OCT with other techniques for synergistic gains in patient outcome.Supplemental DocumentsVU08120--Sub-Millimeter Diameter OCT ProbesInventorsKaren JoosJin ShenMon, 23 Mar 2009 14:02:19 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1774http://vanderbilt.technologypublisher.com/technology/1773A metering rotary nanopump for driving BioMEMS and microfluidic systems.InventorsScott DarbyRon ReisererDavid SchafferKevin SealeJohn Wikswo, Jr.Mon, 23 Mar 2009 14:02:19 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1773http://vanderbilt.technologypublisher.com/technology/1772Nearly all current commercial transfemoral prostheses are energetically passive devices. That is, the joints of the prostheses either store or dissipate energy, but do not provide net power over a gait cycle. The inability to deliver joint power impairs the ability of these prostheses to restore many locomotive functions, including walking up stairs and up slopes. Further, although less obvious, biomechanically normal walking requires positive power output at the knee joint and significant net positive power output at the ankle joint. Transfemoral amputees walking with passive prostheses have ...Mon, 23 Mar 2009 14:02:18 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1772http://vanderbilt.technologypublisher.com/technology/1771The overall focus of this project is to produce real-time spectroscopic images with variable resolution (low resolution for screening, higher resolution for diagnosis) and automated diagnosis that can be overlaid with black and white spatial images to provide identification of non-normal lesions with high sensitivity for the management of disease through a combined screening and diagnostic device that can be applied in a variety of organ systems. We have developed a single handheld device for combined confocal imaging and confocal Raman spectroscopy as well as gross spatial imaging as a clini...Mon, 23 Mar 2009 14:02:18 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1771http://vanderbilt.technologypublisher.com/technology/1770Copper and precious metal theft is a tremendous problem worldwide, which not only leads to massively increased costs, but often to a dangerous loss of infrastructure in power transmission and communications. Using nanotechnology, objects made from metals such as copper can be invisibly tagged with a unique signature to identify the source of the metal. The nanotags do not influence the properties or appearance of the material, and cannot be removed or destroyed by reworking or melting it.InventorsDavid BrittonJames DickersonMargit HartingMon, 23 Mar 2009 14:02:18 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1770http://vanderbilt.technologypublisher.com/technology/1769A method for simplifying the process of designing a platform for minimally invasive surgery. The platform is designed to attach to a set of bone-implanted anchors attached to the patient. This method makes the fitting of the platform to the anchors simpler and easier.InventorsJ Michael FitzpatrickMon, 23 Mar 2009 14:02:17 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1769http://vanderbilt.technologypublisher.com/technology/1768Our preliminary data show that the efficacy of train stimulation at 7 PPS was identical to the standard continuous stimulation at the same frequency, pulse width, and voltage. If train stimulation at 7 PPS is used, up to 30% of implantable battery energy can be saved. This effect also provides evidence that high frequency STN stimulation has a prolonged effect, namely, 43 ms following 100ms high frequency stimulation. This effect could be important for mechanism study that the stimulation evoked effects last up to 43 ms following 100ms high frequency stimulation. It is believed that the train ...Mon, 23 Mar 2009 14:02:17 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1768http://vanderbilt.technologypublisher.com/technology/1767Three types of technologies have been developed for assisting during breast biopsy procedures. 1) Many robotic systems have been developed to improve accuracy of needle insertions. But these systems do not compensate for tumor movement during the insertion. Hence multiple insertions are typically required to successfully sample the tumor. 2) Steerable needle devices have been developed to guide the needle tip towards the tumor. Even though these systems may not require multiple insertions, they cause tissue damage inside the breast during steering of the needle. 3) Finite element methods have ...Mon, 23 Mar 2009 14:02:17 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1767http://vanderbilt.technologypublisher.com/technology/1766We have developed a technique to process photolithographically porous silicon heterostructures and photonic crystal architectures, using laser and ultraviolet light exposure and a subsequent alcoholic bath treatment. This technique would be the first method to process directly the optical properties of porous silicon multilayers, heterostructures, and photonic crystal architectures.InventorsJames DickersonDavid HarjuHeungman ParkAlex StramelSharon WeissMon, 23 Mar 2009 14:02:16 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1766http://vanderbilt.technologypublisher.com/technology/1765Previously we have demonstrated a fundamentally novel device for neural activation using low-level, pulsed infrared laser energy in vivo with resulting compound nerve and muscle potentials and associated muscle contraction. We also show that infrared laser light incorporated into a stimulation device at 4.0 and 2.1 ?m can be used to consistently and reproducibly stimulate peripheral nerves in frogs and rats with no appreciable tissue damage. The purpose of this disclosure is to supplement the methodology of optical stimulation and optical stimulation device. Here we describe a novel method for...Mon, 23 Mar 2009 14:02:16 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1765http://vanderbilt.technologypublisher.com/technology/1764Dilator designed for ease of use by OBGYN physicians and to greatly reduce discomfort to patients. In obstetric procedures, a pregnant patient may present with the complication of a cervix that cannot dilate on its own. Current dilation methods all have the potential of harmful or undesirable side effects or consequences. This device presents an alternative method for cervical dilation that is safer than the existing mechanical or pharmacological methods. It has more precise control of the rate of dilation, as well as requiring less direct supervision by medical staff. The device presents no a...Mon, 23 Mar 2009 14:02:15 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1764http://vanderbilt.technologypublisher.com/technology/1763This technology is a system for 3D imaging of live biological cells fabricated using conventional semiconductor technology that provides simultaneous images from multiple vantage points. InventorsRon ReisererKevin SealeJohn Wikswo, Jr.Mon, 23 Mar 2009 14:02:15 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1763http://vanderbilt.technologypublisher.com/technology/1762The postoperative neurological management of patients with deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease is a complex and dynamic process that involves optimizing the stimulation parameters and decreasing the anti-parkinsonian medication while assessing the interactions of both treatment modalities. In clinical practice, finding the optimal programming parameters can be particularly difficult soon after the placement of DBS electrodes. This technology provides a computerized system to assist neurologists with one of the bottlenecks of deep brain stimulat...Mon, 23 Mar 2009 14:02:15 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1762http://vanderbilt.technologypublisher.com/technology/1761This technology is a platform, device and system that provides percutaneous access to the cochlea for otologic surgery. While image guidance technology is used to arrive at a trajectory for access to the cochlea from the outer surface of the mastoid, this platform provides the necessary support to the surgical drill. The platform itself is supported on three skull-implanted anchors which can also be used to adjust the platform’s position.InventorsJ Michael FitzpatrickRobert LabadieMon, 23 Mar 2009 14:02:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1761http://vanderbilt.technologypublisher.com/technology/1760The following conclusions are made concerning unsupported VO2 syntheses presented here: • Controlling the concentration of NH3(aq) catalyst in the inverse micelle reaction of VO(OiPr)3 is not adequate for (1) reducing premature precipitation from inverse micelles, (2) minimizing agglomeration of particles, or (3) controlling the reduction of V(V) precursors for the preparation of VO2 nanoparticles. • The onset of turbidity in the inverse micelle reaction of a VO(OiPr)3/oleic acid premix is prolonged by decreasing the concentration of NH3(aq) catalyst. • The inverse micelle ...Mon, 23 Mar 2009 14:02:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1760http://vanderbilt.technologypublisher.com/technology/1759A surgical platform usable for performing a surgical procedure. In one embodiment, the surgical platform comprises a base portion configured to receive at least one probe; a plurality of adjustable legs configured to support the base portion, each adjustable legs having a first end portion and an opposite, second end potion defining a length therebetween; and at least one movable portion configured to adjust the length of at least one adjustable leg.InventorsJ Michael FitzpatrickChangquing KaoPeter KonradRobert LabadieMon, 23 Mar 2009 14:02:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1759http://vanderbilt.technologypublisher.com/technology/1758Hydrocarbons can serve as room-temperature sources of clean hydrogen gas suitable for running a hydrogen/air fuel cell. It solves many perplexing problems associated with the hydrogen storage problem for fuel cell technologies.InventorsCharles LukehartMon, 23 Mar 2009 14:02:13 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1758http://vanderbilt.technologypublisher.com/technology/1757Unique drill bit design that enables a quick, precise preparation of the perforation site without multiple trial time-consuming manual preparations of the surface. InventorsGilbert HumbertChangquing KaoPeter KonradMon, 23 Mar 2009 14:02:13 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1757http://vanderbilt.technologypublisher.com/technology/1756Mon, 23 Mar 2009 14:02:13 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1756http://vanderbilt.technologypublisher.com/technology/1754Currently practical (as opposed to didactic) training is performed by trainees practicing on live patients and then learning disease processes from mentors. The training is serendipitous by necessity. This technology would potentially shorten, standardize, and broaden the training for technicians as well as radiologists and surgeons.InventorsAlan HerlineJohn WarmathMon, 23 Mar 2009 14:02:12 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1754http://vanderbilt.technologypublisher.com/technology/1753Users and makers of SOI wafers presently employ destructive, non-real-time methods to characterize the buried layer and interfaces of the SOI wafers. The second harmonic generation (SHG) technique implemented into an automated metrology tool configuration provides a non-invasive method to characterize and monitor the quality of the interfaces in a production mode (i.e. high sample frequency, real-time) replacing, or at minimum reducing the need for, some of the destructive measurements and improving feedback time. Implementation of the SHG methodology can leverage existing tool platform infras...Mon, 23 Mar 2009 14:02:12 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1753http://vanderbilt.technologypublisher.com/technology/1752Simple device to assist in selection of appropriate sized mesh/tissue graft for abdominal wall hernia repair. This device will then be utilized to "stretch" the material flat removing redundancies/folds. Once "flattened" the material can be pulled to the abdominal wall without the need for multiple instruments. The mesh/tissue graft can then be appropriately positioned over the defect to assure adequate material overlap. Once positioned the material is fixed in place with traditional techniques. The device can also be used in a similar fashion via a natural orifice transluminal endoscopic surg...Mon, 23 Mar 2009 14:02:11 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1752http://vanderbilt.technologypublisher.com/technology/1751This intraoperative parathyroid detector easily distinguishes parathyroid glands from thyroid, lymph node, and even fatty tissue. Most of our current methods of localizing parathyroid glands involve expensive radiologic studies that require coordination with nuclear medicine teams. Our probe allows instant detection of the parathyroid without exposing patients to the extra radiation, contrast injection, or valuable time needed to obtain the old studies. In addition, it allows young surgeons to operate with the confidence of much more experienced surgeons. It takes away the guesswork involved i...Mon, 23 Mar 2009 14:02:11 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1751http://vanderbilt.technologypublisher.com/technology/1750Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest._ Supplemental DocumentsVU07114--PosiSeat Assured Seating of Threaded Surgical ComponentsInventorsJ Michael FitzpatrickRobert LabadieJason MitchellMon, 23 Mar 2009 14:02:10 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1750http://vanderbilt.technologypublisher.com/technology/1749Utilizing force sensors mounted on the friction stir welding tool, Vanderbilt inventors have developed a technique to keep a weld tool on track. This technology is especially benefi cial in real time corrections for deviations in travel in the case of robotic FSW or "blind" welds.Supplemental DocumentsVU0897--Through the Tool Tracking for Friction Stir WeldingInventorsGeorge CookDavid DeLappPaul FlemingDaniel HartmanDavid LammleinAlvin StraussDon WilkesMon, 23 Mar 2009 14:02:10 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1749http://vanderbilt.technologypublisher.com/technology/1748Vanderbilt inventors have developed and tested a device (C-in™) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure. Supplemental DocumentsVU0595--Percutaneous Cochlear ImplantationInventorsJ Michael FitzpatrickRobert LabadieMon, 23 Mar 2009 14:02:10 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1748http://vanderbilt.technologypublisher.com/technology/1746The solenoid-based technology provides a four-way valve and double-acting cylinder that are fully interchangeable with a standard four-way solenoid valve and double-acting cylinder combination, do not add significantly to the production costs of these components, and reduce the average airflow requirements by 40% relative to the standard combination, for the same supply pressure input and motion output.InventorsMichael GoldfarbXiangrong ShenMon, 23 Mar 2009 14:02:09 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1746http://vanderbilt.technologypublisher.com/technology/1745There are approximately 500,000 surgeries performed per year addressing issues of spinal disc degeneration. Though nearly all of these surgeries are spinal fusions, there is increasing interest in functional intervertebral disc replacement (i.e., joint arthroplasty). A recent report entitled "Emerging Technologies in Spinal Motion Preservation," published by Espicom Healthcare Intelligence in October 2006 states "By 2011, (spinal) motion preservation technologies will achieve revenues of US $5.1 billion and account for 50% of the (spine surgery) market." Some commercial artificial spinal discs...Mon, 23 Mar 2009 14:02:09 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1745http://vanderbilt.technologypublisher.com/technology/1744Vanderbilt researchers have developed a process that creates free standing nanocrystalline thin films using a simple, robust and cost efficient process. This paves the way for manufacturing conformal films of nanocrystals at a fraction of the cost as compared to techniques currently used. The process could be applied in the manufacture of a number of end products such as solar cells, supercapacitors, magnetic storage, semiconductor devices and catalysis. Supplemental DocumentsVU0815--Free Standing Nanocrystal Thin FilmsInventorsJames DickersonSaad HasanMon, 23 Mar 2009 14:02:08 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1744http://vanderbilt.technologypublisher.com/technology/1741These valves enable high-bandwidth proportional control of cold gas, hot gas, and/or liquid flow in relatively low-cost packages. With regard to 2-way liquid valves, there are no comparable products on the market (i.e., commercially available valves in this size range are on/off valves, which do not provide adequate control resolution for many applications). With regard to gas valves, all known cold gas 3-way and 4-way servovalves are linearly actuated, which increases cost and size and decreases performance relative to our designs. Further, there are no hot gas control valves in this size cat...Fri, 20 Mar 2009 14:30:51 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1741http://vanderbilt.technologypublisher.com/technology/1740Vanderbilt inventors have developed a computer-assisted feedback triggered surgical disablement device. This system generates a warning and then disables a surgical device when the surgeon approaches tissue outside of the selected operating tissue. This system allows a safety mechanism to be implemented ensuring surgical accuracy.InventorsJ Michael FitzpatrickRobert LabadieFri, 20 Mar 2009 14:30:50 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1740http://vanderbilt.technologypublisher.com/technology/17391) The visualization (2D and 3D) of images. Its main area of application is the visualization of tomographic medical images data sets 2) the interaction with these data sets. The software permits the manual alignment of data sets, the delineation of regions of interest (both in 2D and in 3D), the import and export of these regions of interest, the display of these regions both as contours or as surfaces, as well as the processing of the images (filtering, image enhancement, etc.) 3) The registration of medical images. This software has been designed to permit the realignment of multiple data s...Fri, 20 Mar 2009 14:30:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1739http://vanderbilt.technologypublisher.com/technology/1738A method of producing colloidal, shaped nanoparticles of a transition metal or alloys thereof, comprising reducing ions of at least one transition metal in an aqueous solution thereof in the presence of at least one compound, which, at its isoelectric point, is a zwitterion and/or at least one small, non-polymeric anion and the nanoparticles produced thereby.InventorsCharles LukehartJason MichelFri, 20 Mar 2009 14:30:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1738http://vanderbilt.technologypublisher.com/technology/1737A method of optimal placement of a deep brain stimulator in a targeted region of a brain of a living subject for optimal deep brain stimulation. In one embodiment, the method includes the steps of nonmanually selecting an initial optimal position from, refining the nonmanually selected initial optimal position to determine a final position, and placing the deep brain stimulator at the final position in the targeted region of the brain of the living subject. WebsiteFor more information about Optimal Placement of Deep Brain StimulatorInventorsEbru CetinkayaBenoit DawantJ Michael FitzpatrickPeter...Fri, 20 Mar 2009 14:30:49 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1737http://vanderbilt.technologypublisher.com/technology/1736Simon (Signal Interpretation and Monitoring) is an ongoing research and development effort at Vanderbilt University. Simon's overall goal is to provide effective computerized medical decision support in critical care through novel collection, analysis, and presentation of physiologic data from bedside medical devices.WebsiteMore about SIMONInventorsBenoit DawantPatrick NorrisFri, 20 Mar 2009 14:30:48 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1736http://vanderbilt.technologypublisher.com/technology/1735An educational module for upper-level bioprocess/bioengineering students to develop a metabolic model for reactions that create cellular energy, design a feasible measurement plan, calculate estimates for fluxes, and then use statistical measures to assess the consistency of the measurements to the model they created. InventorsR. Robert BalcarcelSean BrophyFri, 20 Mar 2009 14:30:48 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1735http://vanderbilt.technologypublisher.com/technology/1734Elastography is the direct imaging of tissue elasticity parameters. The invention is a method of modeling of tissue called Modality Independent Elastography (MIE), within the context of dermoscopy imaging, for the purpose of optimizing the similarity between model-created images and the patient acquired images. InventorsMichael MigaFri, 20 Mar 2009 14:30:48 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1734http://vanderbilt.technologypublisher.com/technology/1732This technology is fundamentally a new way to align a patient in an image-guided surgery system (registration) without the use of fiducial markers on the cranium exterior. The system utilizes laser range scanning technology, the natural features on the cortical surface, and the corresponding natural features derived from the patient’s preoperative magnetic resonance tomograms. In addition, the technology is amenable to measuring deformation (brain shift) for use within a mathematical model-based strategy for shift compensation. Supplemental DocumentsVU03106--Laser Range Scanning for Cortical S...Fri, 20 Mar 2009 14:30:47 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1732http://vanderbilt.technologypublisher.com/technology/1730This program permits the automatic non-rigid registration (spatial realignment) of 2D and 3D mono-modal medical images. The algorithm is based on optical flow principles.InventorsBenoit DawantShiyan PanFri, 20 Mar 2009 14:30:46 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1730http://vanderbilt.technologypublisher.com/technology/1729This program permits the automatic non-rigid registration (spatial realignment) of 2D and 3D mono-and multi modal images.InventorsAkram AldroubiBenoit DawantGustavo RohdeFri, 20 Mar 2009 14:30:46 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1729http://vanderbilt.technologypublisher.com/technology/1728This program permits the automatic registration (spatial realignment) of 2D and 3D mono- and multi-modal medical images. In its current form it uses Mutual Information as the similarity measure. It supports multi-resolution schemes and transformations up to 12 degrees of freedom.InventorsBenoit DawantRui LiFri, 20 Mar 2009 14:30:46 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1728http://vanderbilt.technologypublisher.com/technology/1727A flexible endoscope for ophthalmic orbital surgery is presented. The endoscope has illuminating fiber, image fiber and a free conduit to deliver purge gas/fluid in addition to instruments such as ablation instruments, coagulating instrument or a medication delivery instrument. InventorsRobert Galloway, Jr.Louise MawnFri, 20 Mar 2009 14:30:45 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1727http://vanderbilt.technologypublisher.com/technology/1726A fiducial marker holder apparatus includes a maxillary holding device and an open-ended frame. The maxillary holding device is configured to be temporarily secured to only a maxillary-region of a patient. The open-ended frame has first and second arms and is configured to be removably attached to the maxillary holding device. The first arm has at least one marker attachment point that receives fiducial markers and the second arm has a plurality of marker attachment points that receive fiducial markers. At least two of the marker attachment points of the second arm are configured to receive fi...Fri, 20 Mar 2009 14:30:45 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1726http://vanderbilt.technologypublisher.com/technology/1724A new magnetic pump consisting of two main parts: a main pump body and an external check-valve-bridge. This pump is capable of scale-up to much larger sizes than currently available pumps. InventorsYuqing DingM. Douglas LeVanFri, 20 Mar 2009 14:30:44 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1724http://vanderbilt.technologypublisher.com/technology/1723A phase-contrast X-Ray computed tomography scanner, a monochromatic diffraction computed tomography scanner, a rotatable monochromatic diffraction computed tomography scanner, and a combination phase-contrast and monochromatic computed tomographic scanner are provided. In addition, a method of identifying an unknown sample is provided. InventorsEdwin DonnellyRon PriceFri, 20 Mar 2009 14:30:44 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1723http://vanderbilt.technologypublisher.com/technology/1722Native tumorous and non-tumorous tissues and thermally denatured tissues can all be identified optically in patient livers by means of one or more probes inserted into the liver. Fluorescence and/or diffuse reflectance values can be used for initially locating a tumorous mass, effectively centering a thermal ablation device within a tumor, monitoring ablation of the tumor about the tumor to assure effective denaturation of the tumor, and locating the mass of denatured tissue after the thermal denaturation treatment and after the treated tissue has returned to the temperature of the untreated s...Fri, 20 Mar 2009 14:30:43 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1722http://vanderbilt.technologypublisher.com/technology/1721This invention combines the microfluidic and microelectronic devices and techniques required for the microminiaturization of cell culture and cell measurement systems to allow monitoring the response of populations of 1 to several hundred living cells. The instrument(s) allows for the detection of extracellular, membrane, and intracellular parameters; and the incorporation of closed-loop control techniques to continuously monitor the health of the cell and adjust the environmental and pharmacological parameters that control the cell. InventorsR. Robert BalcarcelTed BaptyFranz BaudenbacherLinds...Fri, 20 Mar 2009 14:30:43 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1721http://vanderbilt.technologypublisher.com/technology/1720Systems and methods involving monopropellant and hypergolic powered proportional actuators that may be used in applications such as robotics. A blowdown tank delivers fuel to a reaction site, produce gaseous products. Those gaseous products are transported to a pressure reservoir or directly to the actuator. The gaseous products are controllably introduced into the actuator to actuate a piston. The piston may be used to power a host of devices including robots. Energy and power densities are significantly greater than a DC motor and battery combination; projected to provide 7 to 12 times bette...Fri, 20 Mar 2009 14:30:43 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1720http://vanderbilt.technologypublisher.com/technology/1719Transcend is a model-based diagnosis system for fault detection and isolation of abrupt faults in complex to very complex engineered systems. It applies models of dynamic system behavior to obtain accurate predictions for measured transients and compares predictions with actual observations to distill the true cause for the faulty behavior. To successfully perform diagnosis, Transcend needs a dynamic model of the system. InventorsGautam BiswasEric MandersPieter MostermanFri, 20 Mar 2009 14:30:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1719http://vanderbilt.technologypublisher.com/technology/1718A clamp with helical coils or springs to receive and secure cylindrical rods; e.g., for external fixators. The clamp includes quick connection and tightening around the rod . These clamps have multiple uses including use as a device for securing a bone, scaffolding, and other applications where gripping 360 degrees around the rod offers significant advantage. InventorsJohn DawsonJeff GordonMark McAndrewFri, 20 Mar 2009 14:30:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1718http://vanderbilt.technologypublisher.com/technology/1717A catheter device for therapeutic and diagnostic use within a human vascular system in difficult to access locations such as bifurcating cerebral arteries. The distal end of the catheter body comprises a flexible material so that the catheter tip can deflect laterally towards the vessel wall in response to the hemodynamic lift. An intermediate section of the catheter body between the hub and the tip provides a semi-rigid control connection whereby pushing, pulling, and rotation of the hub produces a corresponding movement of the catheter tip. InventorsTheodore Larson IIIMark McQuainRobert Rose...Fri, 20 Mar 2009 14:30:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1717http://vanderbilt.technologypublisher.com/technology/1716In this device, a low voltage power supply produces a flow of electrons which are subsequently accelerated by a high voltage power supply. The production of electrons is enhanced by making the emissive cathode components out of highly emissive materials such as filed emitter diodes and the like. Upon impact with an anode these accelerated electrons produce X-rays. The produced X-Rays then exit the structure via a port or series of ports in the cathode. The utility of such a device is in the fact that they are miniature X-Ray sources and can be in the form of a matrix of sources.InventorsRobert...Fri, 20 Mar 2009 14:30:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1716http://vanderbilt.technologypublisher.com/technology/1715This new materials processing technology allows metal and ceramic parts to be manufactured in three dimensions by additive deposition of material, either in atmosphere or in a vacuum. The scale is on the order of the powder size and can be as small as one micron. The deposition rate can be orders of magnitude greater than vapor deposition, which is the current vacuum fabrication technology for devices.InventorsDavid GustafsonWilliam HofmeisterBridget RogersFri, 20 Mar 2009 14:30:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1715http://vanderbilt.technologypublisher.com/technology/1714The invention is a novel ranging method based on a switched antenna array generating a quasi-doppler RF signal. The phase change when switching from one antenna to the next can be measured using the radio interferometric technique developed previously at Vanderbilt. This can be used to calculate bearing information between the transmitter and the receiver. Using three or more nodes at known locations then makes it possible to calculate the locations of receivers. InventorsAkos LedecziJanos SallaiPeter VolgyesiFri, 20 Mar 2009 14:30:40 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1714http://vanderbilt.technologypublisher.com/technology/1713This online program developed at Vanderbilt serves to centralize faculty information. Rocinante™ makes it easier to compile faculty data from across schools. The program is a powerful, easy to use tool that assists faculty in their administrative duties and in grant writing. The “public view” acts as a front-end web-site for each faculty member. Rocinante’s most powerful feature is its ability to mine PubMed for faculty publications. This prevents faculty members from needing to manually link their publications to their information. InventorsRoger ChalkleyFri, 20 Mar 2009 14:30:40 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1713http://vanderbilt.technologypublisher.com/technology/1712KaiNexus addresses many shortcomings of other CQI (continuous quality improvement) implementation tools now on the market. KaiNexus will be a web-based solution that creates a dynamic CQI environment, allowing an organization to learn, organize, teach, implement, and maintain a CQI program. KaiNexus may be the only product providing a web-based solution designed to facilitate a CQI program for a health care organization. KaiNexus It will teach employees to think critically about their own job functions, to look for and identify areas of improvement, and to submit, monitor, organize, and exec...Fri, 20 Mar 2009 14:30:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1712http://vanderbilt.technologypublisher.com/technology/1711The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents w...Fri, 20 Mar 2009 14:30:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1711http://vanderbilt.technologypublisher.com/technology/1710The Fiberoptic Laser Doppler Probe records microvascular blood flow in tissues during surgery, giving a measure of real-time tissue perfusion. It has been used to measure microvascular flow in the facial nerve and cochlea during surgery for removal of vestibular schwannoma tumors. The ability to measure the integrity of the microvascular circulation in the facial nerve and cochlea during tumor dissection permits the surgeon to implement dissection maneuvers when blood flow impairment is identified before permanent damage is done. In the case of vestibular schwannoma surgery, this device can im...Fri, 20 Mar 2009 14:30:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1710http://vanderbilt.technologypublisher.com/technology/1709ListVUe is a software tool that permits the expeditious search of the United States Department of Commerce Export Control with a higher degree of accuracy than is currently available. This product is designed for any company or institution which is required to comply with U.S. export control laws and regulations.Supplemental DocumentsListVUe_-_Executive_SummaryInventorsJohn ChildressMark DorminyFri, 20 Mar 2009 14:30:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1709http://vanderbilt.technologypublisher.com/technology/1708Illuminated Low Vision Glasses enable individuals with significant vision impairments to read. This new technology overcomes the principal factors that prevent individuals with low vision from reading (poor contrast and illumination and unrecognizable letters) by providing illumination, magnification and prism correction. This assistance permits them to read ordinary print. Supplemental DocumentsVU0610--Illuminated Low Vision GlassesInventorsJeffrey SonsinoFri, 20 Mar 2009 14:30:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1708http://vanderbilt.technologypublisher.com/technology/1706Contextualized feedback intervention and training protocol is a form assessment. It enables behavioral healthcare practitioners to assess and categorize the behavioral health status of patients in a mental health context. It also provides a training protocol for providers. InventorsLeonard BickmanManuel RiemerFri, 20 Mar 2009 14:30:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1706http://vanderbilt.technologypublisher.com/technology/1705This technology addresses the problem of designing and implementing online monitoring and diagnosis systems for complex hybrid systems by focusing on faults that occur in plant components and contains models where faults are represented by changes in system parameters. Hybrid systems are common in the avionics, spacecraft, automotive and robotics domains where behavior is characterized by continuous plant dynamics and discrete supervisory control. These hybrid systems require a tool that analyzes and seamlessly integrates multiple system models on a discrete and continuous basis. As a result, ...Fri, 20 Mar 2009 14:30:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1705http://vanderbilt.technologypublisher.com/technology/1704The invention provides methods and devices for repairing a ruptured ligament, meniscus, cartilage, tendon, and bone.InventorsJennifer MarlerMartha MurrayMichael MurrayAenor SawyerKurt SpindlerFri, 20 Mar 2009 14:30:36 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1704http://vanderbilt.technologypublisher.com/technology/1702MOOSES (Multi-Option Observation System for Experimental Studies). This software system makes it easy to collect and analyze data about any type of real time events. Data can be collected using your PC, a laptop, A handheld PC, or a PocketPC and later analyzed on several dimensions. Data collected from digital audio and video files using ProcoderDV can also be analyzed using MOOSES. This type of data can help you make accurate assessment of what is happening in the real time system you are observing. Several analysis options are provided and described at the website.WebsiteGet MOOSESInventorsJ...Fri, 20 Mar 2009 14:30:36 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1702http://vanderbilt.technologypublisher.com/technology/1700Interval Manager (INTMAN) is a computer-assisted alternative to traditional paper and pencil methods for collecting fixed interval time sampled observational data. The INTMAN data collection software runs on Pocket PC hand held computers and includes a desktop application for Microsoft Windows that is used for data analysis. Standard analysis options include modified frequencies, percent of intervals, conditional probabilities, and Kappa agreement matrices and values.WebsiteGet INTMANInventorsJon TappFri, 20 Mar 2009 14:30:35 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1700http://vanderbilt.technologypublisher.com/technology/1699Trains school leaders through the use of challenge based learning modules. This software is cross platform and requires only a media player (i.e., Quick Time Pro or Microsoft Media). These modules contain an introduction to help users navigate the software. The application is fully functional and has been used in a multitude of school settings.InventorsEllen GoldringJames GuthriePearl SimsFri, 20 Mar 2009 14:30:35 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1699http://vanderbilt.technologypublisher.com/technology/1698The FACT toolsuite assists engineers working with complex aerospace systems to design and implement control systems that can maintain control even when the controlled system "fails." The tool suite uses a model-based approach where the designer creates design models of the plant and its associated control system, and the tools automatically generate code that implements fault-detection, isolation and control reconfiguration functions.Supplemental DocumentsVU04130--Fault-Adaptive Control Technology Toolsuite (FACT)InventorsSherif AbdelwahedGautam BiswasGabor KarsaiJanos SztipanovitsFri, 20 Mar 2009 14:30:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1698http://vanderbilt.technologypublisher.com/technology/1697Retractable monitoring (ECG, SPO2, NIBP, Pressure Transducer Cables) cables for OR and Transport monitors as well as ICU to eliminate entanglement and damage that occurs from current systems. Cables will be attached to spring activated, retractable housing that allows for clean, easy storage. Solves problem of damaging tangled cables, as well as dislodging patient implements from tangled cables. InventorsRobert PousmanFri, 20 Mar 2009 14:30:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1697http://vanderbilt.technologypublisher.com/technology/1696Enables children to work with a digital "reading partner" to read and enjoy original books, while building decoding skills and automatic word recognition skills. The software is both Mac and PC compatible. An user's manual is still under development. The software has been beta tested, with research validating its effectiveness with first graders. Additional development is needed to make it product-ready. (Professional voices to be added, some graphics and navigation tools to be added).InventorsDiana SharpFri, 20 Mar 2009 14:30:33 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1696http://vanderbilt.technologypublisher.com/technology/1691This technology utilizes a set of mathematical algorithms that permit fast and robust reconstruction of signals from digital samples without the need to resort to band limitations or uniform sampling. This allows a signal to be digitized in a more sophisticated way, sampling it at frequent intervals when it is rapidly changing, and less often when it is changing slowly. Band limits imposed by uniform sampling are eliminated.Supplemental DocumentsVU0247--Sampling Algorithm for the Reproduction of Complex Digital SignalsInventorsAkram AldroubiFri, 20 Mar 2009 14:30:31 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1691http://vanderbilt.technologypublisher.com/technology/1690The invention provides a very simple, effective and efficient way to eliminate and reverse evaporative loss in high-density sample plates. As genomic research technologies move forward and use higher and higher density plate formats and smaller and smaller volumes, loss of valuable samples to evaporation becomes more and more of a problem. This invention is a simple and effective means of not only eliminating evaporative losses but also reversing evaporative losses that may have occurred previously without time consuming and expensive liquid transfers that could introduce contamination.Invento...Fri, 20 Mar 2009 14:30:31 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1690http://vanderbilt.technologypublisher.com/technology/1687Play Nicely is a video series developed by a professor of pediatrics for parents of and for teachers and day care providers who are responsible for pre-school age children. The video series offers advice on how to deal with anti-social and violent behavior among pre-school children and the best methods for modifying such behavior. WebsiteGet Play NicelyInventorsCarla BealsSeth ScholerFri, 20 Mar 2009 14:30:30 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1687http://vanderbilt.technologypublisher.com/technology/1686The Head Restraint Device for Racecar Drivers device safely slows the forward movement of the head during a crash. The slowing of this forward movement is accomplished by the use of shock absorbing lanyards attached to the helmet containing material that tears. With the correct tensile strength, the device can limit or prevent coup-contrecoup injuries to the brain with a direct impact into a retaining wall at speeds of up to 220 mph. Supplemental DocumentsVU0102--Head Restraint for Racecar DriversInventorsPanasarn JirutAsif LalaL. Jackson RobertsFri, 20 Mar 2009 14:30:30 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1686http://vanderbilt.technologypublisher.com/technology/1685Technology Summary: The technology described here permits the delivery of therapeutic or diagnostic (tumor imaging) molecules to a variety of tumor types in a targeted fashion. Current methods for targeting therapeutic agents to tumors have limited utility because they (i) produce toxic effects through reactions with normal tissues; (ii) lack the ability to bind to multiple tumor types and/or (iii) lack tumor specificity. This technology is based upon the fact that certain proteins are upregulated in blood vessels in response to irradiation. These upregulated proteins can act as targets for...Fri, 20 Mar 2009 14:30:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1685http://vanderbilt.technologypublisher.com/technology/1677The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle chloride channel (hClC-1). The cells enable high throughput screening of compounds that modulate chloride channel activity.InventorsAlfred GeorgeFri, 20 Mar 2009 14:30:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1677http://vanderbilt.technologypublisher.com/technology/1676The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human chloride channel (hClC-4). The cells enable high throughput screening of compounds that modulate chloride channel activity.InventorsChristoph FahlkeAlfred GeorgeFri, 20 Mar 2009 14:30:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1676http://vanderbilt.technologypublisher.com/technology/1673A simple printing tip has been developed to transfer liquids between a fluid reservoir and a substrate surface. Preliminary results suggest that this design can be used to control the spot diameter and the volume transferred in a very reproducible fashion. This later characteristic is of particular value in situations where the substrate surface contains thousands of spots in a microarray format where minimum spot variation is essential.InventorsFrederick HaseltonMark McQuainFri, 20 Mar 2009 14:30:22 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1673http://vanderbilt.technologypublisher.com/technology/1672Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.InventorsAlfred GeorgeChristoph LossinFri, 20 Mar 2009 14:30:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1672http://vanderbilt.technologypublisher.com/technology/1671Vanderbilt scientists have modified the currently used tuberculosis vaccine, bacillus Calmette-Guérin (BCG), so that it accesses the immune system in a manner that produces favorable cellular immune responses. The Vanderbilt vaccine, called “pro-apoptotic BCG (paBCG),” induces very potent antigen-specific T-cell responses (CD4+ and CD8+), including responses to peptides of immunodominant TB antigens. This indicates the potential for inducing similarly strong T-cell responses to recombinant cancer antigens expressed by paBCG. We are currently seeking a partner to help investigate the immune res...Fri, 20 Mar 2009 14:30:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1671http://vanderbilt.technologypublisher.com/technology/1670Free radicals are believed to play a significant role in aging, carcinogenesis and the pathogenesis of many conditions, including atherosclerosis, emphysema, Alzheimer's disease, Parkinson's disease, and others. Antioxidants such as Vitamin E (alpha-tocopherol), a lipid-soluble, radical-trapping antioxidant, protect against free radical damage (lipid peroxidation) by trapping chain-carrying lipid peroxyl radicals. Vitamin E, probucol, and other antioxidants have been shown to reduce the risk of heart disease and other degenerative diseases. Many cosmetic products now contain antioxidants to he...Fri, 20 Mar 2009 14:30:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1670http://vanderbilt.technologypublisher.com/technology/1666We produced a plasmid containing the Fc portion of mouse IgGl (Fc) coupled to human fibroblast growth factor 1 (FGF-1). The plasmid was transformed into E. coli to express the fusion protein. The fusion protein was purified on a heparin sepharose column which has high affinity for the FGF portion of the fusion protein. The purpose of making this protein was to be able to identify cells that express receptors for FGF using flow cytometry. There are multiple fluorochrome labeled antibodies to mouse IgGl. When the fusion protein is bound to FGF receptors on cells, the Fc portion is on the surface...Fri, 20 Mar 2009 14:27:42 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1666http://vanderbilt.technologypublisher.com/technology/1664The availability of a mutant NET that is lacking responsiveness to Calcium and Calcium-linked kinases is envisaged as a novel tool in the screening for novel NET modulators that may influence NET regulation through this pathway. Screens could be conducted using wildtype and mutant NET in parallel to identify molecules selectively supporting regulation through this site to either up or down-regulate NET. Additionally, stable cells and transgenic mice can be engineered to express the mutant NET and allow for studies of calcium-linked NET regulation and its physiological consequences in vitro and...Fri, 20 Mar 2009 14:27:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1664http://vanderbilt.technologypublisher.com/technology/1663These findings describe a novel mode of action of neurotransmitter transporters brought about by a naturally occurring human mutation. This mode of action, spontaneous efflux of intracellular neurotransmitter, can now be advanced as a possible reason for the development of multiple brain diseases where altered chemical signaling of classical neurotransmitters is suspected. The A559V mutation that we have described and cell lines expressing the mutation should be beneficial in screening for medications that can selectively halt DA efflux, and similar mutations could be envisaged in other neurot...Fri, 20 Mar 2009 14:27:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1663http://vanderbilt.technologypublisher.com/technology/1662InventorsRandy BlakelyFri, 20 Mar 2009 14:27:41 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1662http://vanderbilt.technologypublisher.com/technology/1661The only MMP-7-null mouse that has been generated. Used to determine biological function of MMP-7. Mice have been used in more than 10 publications at this point, and will be distributed by a commercial vendor in the near future.InventorsLynn MatrisianCarole WilsonFri, 20 Mar 2009 14:27:40 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1661http://vanderbilt.technologypublisher.com/technology/1660The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.InventorsErika AdkinsRandy BlakelyKeith HenryFri, 20 Mar 2009 14:27:40 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1660http://vanderbilt.technologypublisher.com/technology/1658A novel method of treating human diseases using natural products found in roasted coffee. The use of natural products or derivatives thereof would permit the general public to improve their health without having to use prescription drugs.InventorsTomas de PaulisDavid LovingerPeter MartinFri, 20 Mar 2009 14:27:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1658http://vanderbilt.technologypublisher.com/technology/1657Angioedema is a life-threatening and unpredictable side effect of angiotensin converting enzyme (ACE) inhibitors and ACE/Neutral endopeptidase (NEP) inhibitors, drugs aimed at reducing cardiovascular mortality associated with a variety of disease states. This technology permits the identification of individuals at risk for developing this angioedemic condition as a result of taking ACE inhibitors or NEP inhibitors. The patents and patent applications claim biological markers, diagnostic methods and kits.InventorsNancy BrownKyung Soo KimLaine MurpheyMarshall SummarFri, 20 Mar 2009 14:27:39 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1657http://vanderbilt.technologypublisher.com/technology/1656InventorsSusan McGrewJohn PhillipsFri, 20 Mar 2009 14:27:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1656http://vanderbilt.technologypublisher.com/technology/1655Vanderbilt researchers have uncovered a novel finding for the toxin from Group beta-hemolytic Streptococcus bacteria (GBS toxin). This group has shown that the GBS toxin may be used as vascular targeting agent to destroy pathological vasculature present in malignant tumors, atherosclerosis, rheumatoid arthritis and chronic wounds.Supplemental DocumentsVU9861--GBS Toxin ReceptorInventorsChanglin FuCarl HellerqvistFri, 20 Mar 2009 14:27:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1655http://vanderbilt.technologypublisher.com/technology/1654InventorsMartin BlaserJoel DworkinStuart ThompsonFri, 20 Mar 2009 14:27:38 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1654http://vanderbilt.technologypublisher.com/technology/1653Vanderbilt researchers have uncovered a novel finding for the toxin from Group beta-hemolytic Streptococcus bacteria (GBS toxin). This group has shown that the GBS toxin may be used as vascular targeting agent to destroy pathological vasculature present in malignant tumors, atherosclerosis, rheumatoid arthritis and chronic wounds.Supplemental DocumentsVU9615--Method of Purification of GBS Toxin-CM101InventorsCarl HellerqvistFri, 20 Mar 2009 14:27:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1653http://vanderbilt.technologypublisher.com/technology/1652InventorsAllen NaftilanRampyari WaliaFri, 20 Mar 2009 14:27:37 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1652http://vanderbilt.technologypublisher.com/technology/1651InventorsMartin BlaserTimothy CoverHarry KleanthousMurali TummuruFri, 20 Mar 2009 14:27:36 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1651http://vanderbilt.technologypublisher.com/technology/1650Ultraviolet radiation, from sunlight causes DNA damage, which can lead to mutations that can develop into skin cancer in humans. Interestingly, viruses that infect bacteria, bacteriophage, contain an enzyme, T4 endonuclease V, which can repair DNA damage induced by ultraviolet light. This enzyme is routinely used in laboratories as a research tool however until recently it has not been shown to have specific activity in human cells, do to its loss of activity in low salt concentrations. Vanderbilt researchers have modified this enzyme such that its specific activity is increased in low salt co...Fri, 20 Mar 2009 14:27:35 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1650http://vanderbilt.technologypublisher.com/technology/1648Dr. Piston’s group has generated a variant of the enhanced cyan fluorescent protein (ECFP) that has improved brightness, more resistance to photo-bleaching and a fluorescence lifetime that is best fit by a single exponential.Supplemental DocumentsVU0427--Variants of Cyan Fluorescent Protein with Improved Fluorescent PropertiesInventorsDavid PistonMark RizzoFri, 20 Mar 2009 14:27:35 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1648http://vanderbilt.technologypublisher.com/technology/1647Phosphodiesterase-5 (PDE5) is an enzyme which degrades cyclic guanosine monophosphate (cGMP) in smooth muscle cells. The common known drug Viagra is similar in molecular structure to cGMP and acts as a competitive binding agent of PDE5. Thus in the presence of Viagra unbound cGMP levels increase which results in smooth muscle relaxation or vasodilation leading to an increased inflow of blood. Vanderbilt researchers have developed a method for assaying compounds which bind PDEs. Not only will this method be useful in identify other PDE inhibitors but due to the high affinity of this system this...Fri, 20 Mar 2009 14:27:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1647http://vanderbilt.technologypublisher.com/technology/1646An electrophoresis chamber having the separation capability of a thicker chamber by the addition of a number of ports along the length of the chamber that can act as inlets or outlets. The device introduces cross flow by either a plurality of input and output ports along opposite walls of the chamber or by a tapered chamber having a plurality of output ports. Since the mobility of the particles is lateral to the direction of flow and the cross flow velocity is opposite in direction and greater than the maximum electrophoretic velocity of the particles being separated such particles are carried...Fri, 20 Mar 2009 14:27:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1646http://vanderbilt.technologypublisher.com/technology/1645It is estimated that approximately 30% of men have reduced fertility and 2% are totally infertile. Despite these large numbers relatively little is know about the molecular bases of male infertility. On the flip side of male infertility is the need for male contraception. Currently there are no reversible, convenient male contraceptives available. In order to develop male contraceptives and acquire a greater understanding of male fertility there is a need to develop animal models to study the molecular basis and pathways that regulate and control male fertility. Vanderbilt researchers have dev...Fri, 20 Mar 2009 14:27:34 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1645http://vanderbilt.technologypublisher.com/technology/1644This technology facilitates the discovery and design of novel agents for either repelling or otherwise controlling insects that have important economic or medical significance. In particular, mosquitoes are responsible for transmitting a number of diseases, including malaria, West Nile, dengue and yellow fevers. The Zwiebel laboratory has identified human odorants and the protein receptors in mosquitoes that allow female mosquitoes to identify their hosts when they need blood to satisfy their reproductive needs. With funding from the Gates Foundation’s Grand Challenge in Global Health initiat...Fri, 20 Mar 2009 14:27:33 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1644http://vanderbilt.technologypublisher.com/technology/1643This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.InventorsMicheala AldredPatrick ConneallyTatiana ForoudRadhika GaddipatiDan KollerKirk LaneEmily LoydJames LoydRaji...Fri, 20 Mar 2009 14:27:33 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1643http://vanderbilt.technologypublisher.com/technology/1642The Canonical Clinical Problem Statement System (CCPSS) is a knowledge base that represents and codes patients’ clinical problems. It differs from existing medical coding schemes because it is clinically relevant and contains clinical knowledge regarding the complex interrelationships between medical problems. The CCPSS could form the basis for construction of more thorough and accurate electronically accessible problem lists and will permit epidemiologic studies of problems across institutions. Partial funding for development of the CCPSS project was from the National Library of Medicine (N...Fri, 20 Mar 2009 14:27:32 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1642http://vanderbilt.technologypublisher.com/technology/1641Vanderbilt researchers have described a unique pathoangiogenic target, HP59, which is recognized by a toxin from Group beta-hemolytic Streptococcus bacteria (GBS toxin), named CM101, as it entered clinical trials in cancer patients. This group has shown that the GBS toxin/CM101 target, HP59, a unique membrane protein, is only present in pathological vasculature. Monoclonal antibodies generated against this target recognize pathologic vasculature in all mentioned disease processes and constitute potential diagnostic and therapeutic agents, which may offer protection against diseases, which have...Fri, 20 Mar 2009 14:27:32 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1641http://vanderbilt.technologypublisher.com/technology/1640The Patient Safety Screening Tool (PSST) for Sepsis solution is a tool to assist with the early detection of Sepsis and management of the administration of bundle packages as defined by the Institute for Healthcare Improvement (IHI). This web based application relies on integration with bedside medical equipment (BME) data as well as Lab and Registration data so that clinical workflow items can be automated in the fight against Sepsis.WebsiteFor more information about PSST for SepsisInventorsJohn BarwiseLeland LancasterFri, 20 Mar 2009 14:27:32 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1640http://vanderbilt.technologypublisher.com/technology/1639Visit Express is an easy to use patient facing kiosk offering HIPAA compliant electronic sign-in for outpatient clinical settings. Visit Express utilizes patient appointment information from existing scheduling systems to verify basic demographic information and enable clinic staff to track the arrival and check-in processes in busy and at times chaotic waiting room environments. Pilot results indicate front desk workflow time savings of up to 25%.Supplemental DocumentsVU0683--Visit ExpressInventorsDewey HuntFri, 20 Mar 2009 14:27:31 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1639http://vanderbilt.technologypublisher.com/technology/1638The Healthcare Matrix is a systematic approach to improving care while teaching the mandated physician competencies. It identifies issues of safety (very prominent in the news), communication (the biggest source of adverse events), timeliness, effectiveness, efficiency (cost, waste, and workarounds), equity (another issue getting a lot of media attention) and finally patient-centered care.Supplemental DocumentsVU0662--Patient Healthcare MatrixInventorsJohn BinghamDoris QuinnFri, 20 Mar 2009 14:27:31 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1638http://vanderbilt.technologypublisher.com/technology/1637FAST-AIMS allows data pre-processing (peak detection, baseline-subtraction, normalization), feature selection, estimation of classification performance, and classification model generation using mass spectrometry data.InventorsConstantin AliferisNafeh FananapazirAlexander StatnikovFri, 20 Mar 2009 14:27:30 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1637http://vanderbilt.technologypublisher.com/technology/1636Vanderbilt University Medical Center (VUMC) job performance evaluations are part of an annual cycle called performance development in which supervisors and staff members identify and tackle specific job goals with close attention given to the VUMC mission, credo and job descriptions. Many hospital systems, including VUMC, now desire to base annual salary increases largely on performance evaluation ratings. VPES and the Job Description Database allow performance evaluations to be applied consistently and efficiently across the organization.Supplemental DocumentsVU0550--Vanderbilt Performance Ev...Fri, 20 Mar 2009 14:27:30 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1636http://vanderbilt.technologypublisher.com/technology/1633Gene Expression Model Selector (GEMS) is a system that constructs, in a supervised fashion, diagnostic and outcome prediction models from array gene expression data. Examples of such models are: (a) models that detect cancer, (b) models that determine the correct subtype of cancer or (c) models that predict survival after treatment. Models that support such complex decision making are widely recognized as having the potential to revolutionize medicine in the years to come. In addition to the decision support models, GEMS can be used to select a small number of genes that are as good or better ...Fri, 20 Mar 2009 14:27:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1633http://vanderbilt.technologypublisher.com/technology/1632The Sneeze Station was originally designed by the Vanderbilt Department of Emergency Preparedness on the heels of the concerns with SARS and other infectious diseases. Validation of market demand for such a device is highlighted by both a recent Wall Street Journal article, which described the need for sanitation products in hospitals, as well the many requests that Vanderbilt has received from other hospitals desiring to purchase the Stations. While demand from end users is promising, it also appears likely that the Sneeze Station medium could be used in marketing activities. Imagine utilizin...Fri, 20 Mar 2009 14:27:29 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1632http://vanderbilt.technologypublisher.com/technology/1631In the past, looking up information on a medical concept could take a student hours of searching through old class notes and textbooks and scouring through medical websites. Vanderbilt's new web-based database, KnowledgeMap, is making the process much easier. The database includes documents created by medical school teachers for their classes (e.g. handouts, PowerPoint slides and web links) in a searchable format. Users are able to type in a concept and quickly discover where it is covered throughout the medical school curriculum, and subsequently view those documents in which the concept is d...Fri, 20 Mar 2009 14:27:28 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1631http://vanderbilt.technologypublisher.com/technology/1630This software allows core managers to enter orders into the system. It also allows customers in product cores to scan their items at a self-service checkout terminal. These orders are accumulated into electronic invoices and e-mailed to the customers each month. An electronic upload file containing order information is also created for the finance department. The system also contains a physical inventory module and receiving module for the product cores.WebsiteFor more information about CORESInventorsRoger AllbeeKeith DanceMark MagnusonJohn ManningFri, 20 Mar 2009 14:27:28 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1630http://vanderbilt.technologypublisher.com/technology/1627Causal Explorer (CE) is a library of causal discovery algorithms authored by the researchers at the Discovery Systems Laboratory in the Department of Biomedical Informatics at Vanderbilt University. CE offers a wide variety of major prototypical and state-of-the-art algorithms in the field and a unified and easy-to-learn programming interface. The output of CE algorithms may include direct or indirect causes or effects of a target variable of interest. CE is designed for all researchers performing data analysis with the desire to gain an understanding in the underlying causal mechanisms that g...Fri, 20 Mar 2009 14:27:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1627http://vanderbilt.technologypublisher.com/technology/1625Fri, 20 Mar 2009 14:27:26 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1625http://vanderbilt.technologypublisher.com/technology/1624Vanderbilt researchers have discovered and patented a means of selectively expressing genes of interest in specific cells. This research tool allows an inactive nucleic acid to be delivered to a specific cell of interest and then the researcher can activate the nucleic acid by exposure to light. This system allows temporal controlled expression over exogenous nucleic acids only in targeted cells or selectively regulating endogenous gene expression.InventorsSteve AlexanderFrederick HaseltonFri, 20 Mar 2009 14:27:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1624http://vanderbilt.technologypublisher.com/technology/1623Approximately 5% of patients administered gentamicin, a common antibiotic, experience vestibular ototoxicity, or poisoning of the inner ear resulting in balance dysfunction such as vertigo, dizziness, and imbalance. Vanderbilt researchers and University of Maryland researchers have identified three specific polymorphisms in susceptible genes that are associated with this disorder. These results maybe used for personalized medicine such that a patient could be screened prior to administering the drug allowing the physician to alter the treatment plan for patients that would be at an increased r...Fri, 20 Mar 2009 14:27:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1623http://vanderbilt.technologypublisher.com/technology/1622Autism is a brain development disorder characterized by impaired social interaction, impaired communication, and restricted and repetitive behavior, all starting before a child is three years old. Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether autism is explained more by multigene interactions or by rare mutations. Vanderbilt and University of Miami researchers have identified a small nucleotide polymorphisms (SNP) on chromosome 5 which associates with autism. This SNP could be developed for early detection of this disease. Diagnosis of...Fri, 20 Mar 2009 14:27:25 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1622http://vanderbilt.technologypublisher.com/technology/1621This is a genetically engineered mouse ES stem cell line marking cardiomyocytes with red fluorescent protein (RFP). These cells have been used in high-throughput screens by Vanderbilt researchers for pro-cardiogenic factors. In addition the construct used in this cell line could be used to mark the cardiac progeny of transplanted stem cells, generate stable human ES cell lines, or engineer iPS for cardiac lineage studies.InventorsAntonis HatzopoulosJianyong HuFri, 20 Mar 2009 14:27:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1621http://vanderbilt.technologypublisher.com/technology/1619Late-Onset Alzheimer’s Disease (LOAD) is a complex disorder with a strong genetic component. Previous studies suggest that genetic variants contribute to not just LOAD susceptibility, but to the variation of the age-at-onset (AAO). Millions of people suffer from this disease but until now there has been no way to predict the probably age at which the disease would begin to manifest. A genome-wide analysis of multitude of single nucleotide polymorphism (SNP’s) was performed on a large population of patients. The importance of identifying SNP’s that are associated with a disease allows the compa...Fri, 20 Mar 2009 14:27:24 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1619http://vanderbilt.technologypublisher.com/technology/1618Depression of Alzheimer disease affects up to half of those suffering from Alzheimer disease. However, little is known regarding the genetic etiology of this depression. Genetic studies of both Alzheimer’s and depression have been frustrated by lack of replication. In part, this may reflect both genetic and phenotypic heterogeneity. Vanderbilt and Miami researchers have found that depression results from two different common neurodegenerative diseases. This represents the first positive report for genetic association for either Depression of Alzheimer’s or Parkinson’s Disease with depression.I...Fri, 20 Mar 2009 14:27:23 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1618http://vanderbilt.technologypublisher.com/technology/1617Age-related Macular Degeneration (AMD) is the leading cause of blindness in elderly patients in developed countries, affecting approximately 7.5 million Americans. Recently several genetic and environmental factors have been implicated as susceptibility factors. We have developed an algorithm which can incorporate all of the risk factors a patient may have and determine a risk value for which they may be susceptible for developing AMD. Currently there is no predictive test for identifying individuals that are at risk for developing AMD rather individuals are screened after the age of 60 for th...Fri, 20 Mar 2009 14:27:22 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1617http://vanderbilt.technologypublisher.com/technology/1615Vanderbilt researchers have enhanced the CreloxP system by reconstituting Cre activity from Cre protein fragments. This reconstitution recovers substantial Cre activity, 8 fold more than other reconstructive systems. In addition, this invention allows for restricting Cre activity selectively in cells that express dual protein markers, allowing greater specificity of Cre expression.Supplemental DocumentsVU0798--Enhancement of the Cre-loxP SystemInventorsGuoqiang GuYanwen XuFri, 20 Mar 2009 14:27:22 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1615http://vanderbilt.technologypublisher.com/technology/1614This technology has identified a genetic marker to aid in the diagnosis of patients with multiple sclerosis as well as to identify patients whom have an increased risk of developing the disease.Supplemental DocumentsGregory et al, Interleukin 7 receptor...InventorsMariano Garcia-BlancoSimon GregoryJonathan HainesMargaret Pericak-VanceSilke SchmidtFri, 20 Mar 2009 14:27:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1614http://vanderbilt.technologypublisher.com/technology/1613Vanderbilt researchers have discovered specific morphogens that can promote differentiation of embryonic stem cells to cardiomyocytes. In addition when these morphogens are added to stem cells during differentiation a 10 to 20 fold increase is seen in cardiomyocyte formation. Thus addition of such morphogens may prove to be a valid therapy for cardiac repair and regeneration.InventorsAntonis HatzopoulosJianyong HuEla KnapikIris MuellerWen-Der WangJingbo YanFri, 20 Mar 2009 14:27:21 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1613http://vanderbilt.technologypublisher.com/technology/1611Vanderbilt researchers have created a data mining tool, Platform for the Analysis, Translation, and Organization of large-scale data (PLATO), that can perform sequential, parallel or any combination of multiple analytical and knowledge-based approaches to extract the maximum information from complex datasets.Supplemental DocumentsVU0652--Platform for the Analysis Translation and Organization of Large Scale Data (PLATO)InventorsJonathan HainesMarylyn RitchieMarshall SummarScott WilliamsFri, 20 Mar 2009 14:27:20 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1611http://vanderbilt.technologypublisher.com/technology/1609Vanderbilt engineers have developed a robust platform for point-of-care (POC) diagnostics applicable to infectious diseases, biowarfare agents and environmental and agricultural testing. This technology uses capture antibodies on a polyester filament, or DNA, on a gold wire that act as molecular hooks to troll for viral or bacterial protein antigens, RNA or capture DNA present in a small biological sample solution. It is envisioned that once the analytical POC device is purchased, a different single-use filament would be sold for each pathogen test of interest.Supplemental DocumentsVU0234--Fil...Fri, 20 Mar 2009 14:27:19 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1609http://vanderbilt.technologypublisher.com/technology/1608The loss of DA neurons is a major feature of Parkinson’s disease and other neurogenerative disorders. Vanderbilt researchers have established an in vivo screen for DA neuron protective agents and genes using the nematode C. elegans. Using green fluorescent protein (GFP) expression in C. elegans DA neurons, researchers have established that the nematode is sensitive to the mammalian neurotoxins that target DA neurons in mammalian models, consistent with an environmentally triggered loss of DA neurons. They also demonstrate that agents that block the nematode DA transporter or genetic ablation o...Fri, 20 Mar 2009 14:27:19 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1608http://vanderbilt.technologypublisher.com/technology/1607This technology enables the delivery of biological molecules into the interior of a cell. Such a delivery mechanism could be utilized in a variety of therapies including peptide, gene transfer and/or antisense therapy.Supplemental DocumentsVU0052--Peptide-Directed Suppression of a Pro-Inflamatory Cytokine ResponseInventorsRobert CollinsJack HawigerYao-Zhong LinDanya LiuXueyan LiuDaniel RobinsonSheila Timmons-DownsRuth Ann VeachFri, 20 Mar 2009 14:27:19 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1607http://vanderbilt.technologypublisher.com/technology/1606Vanderbilt researchers have engineered the piggyBac transposon system creating a highly efficient transposon system with several advantages over the currently used Sleeping Beauty (SB) transposon system. Such features include lack of overproduction inhibition and precise excision. This engineered piggyback system may serve as a valuable tool for a variety of purposes including methods of gene therapy delivery in humans.Supplemental DocumentsWilson et al, Functional zinc finger...InventorsAlfred GeorgeKristopher KahligMatthew WilsonFri, 20 Mar 2009 14:27:18 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1606http://vanderbilt.technologypublisher.com/technology/1605The proposed technology is a lens-shaped soft bag, consisting of elastic silicone rubber and filled with silicone gel. With a special design of the lens bag and the supporting frame, the artificial intraocular lens (IOL) will be able to adjust focal length according to the change of the ciliary muscle. This IOL design has great potential to restore the accommodative function of the patient after cataract extraction surgery. The accommodative intraocular lens includes a frame for engaging the lens structure with the lens capsule of the eye such that contraction of the lens capsule pushes the le...Fri, 20 Mar 2009 14:27:18 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1605http://vanderbilt.technologypublisher.com/technology/1604PK11195 is a high-affinity ligand of the peripheral benzodiazepine receptor (PBR). By linking lanthanide chelates to the PK11195 targeting moiety, Vanderbilt researchers have generated a range of PBR-targeted imaging probes capable of visualizing a number of disease states at cellular levels using a variety of imaging modalities (fl uorescence, PET and SPECT, MRI, electron microscopy).Supplemental DocumentsVU0493--Multimodal Lanthanide Chelate ImagingInventorsDarryl BornhopTimothy GoebelH. Charles ManningFri, 20 Mar 2009 14:27:17 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1604http://vanderbilt.technologypublisher.com/technology/1603Vanderbilt University research has led to the development of a novel near-infrared (NIR) dye for multichannel imaging. It provides the capability to image multiple targets in one environment.Supplemental DocumentsVU0784--Near-Infrared Dye for Optical ImagingInventorsJohn GoreWellington PhamFri, 20 Mar 2009 14:27:17 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1603http://vanderbilt.technologypublisher.com/technology/1602One of the several problems with organ transplantation is the actual procurement of needed organs. The number of patients requiring transplants far exceeds the number of available organs. Thus, tissues and organs from different species (xenografts) may offer help to many more potential organ donors, and consequently may help the organ shortage. However, many obstacles still remain with xenografts, with the major challenge being tissue/organ rejection. The need to reduce this rejection and the injury it can inflict upon the transplanted tissue/organ therefore remains high. Vanderbilt researcher...Fri, 20 Mar 2009 14:27:16 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1602http://vanderbilt.technologypublisher.com/technology/1601Vanderbilt researchers have discovered a novel mechanism through which the insulin regulating enzyme glucokinase is regulated. This discovery provides a powerful way to screen for activators of glucokinase, which may lead to therapies for diabetes.Supplemental DocumentsVU0323--A Method for Regulating Glucokinase by Reaction with Nitric OxideInventorsDavid PistonMark RizzoFri, 20 Mar 2009 14:27:16 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1601http://vanderbilt.technologypublisher.com/technology/1600Fri, 20 Mar 2009 14:27:16 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1600http://vanderbilt.technologypublisher.com/technology/1599Vanderbilt researchers have developed an apparatus and method for fastening a percutaneous medical device to bone. This device is comprised of an anchor, which comprises an outer threaded segment and an inner cavity, comprising an inner threaded segment.Supplemental DocumentsVU0250--Bone Anchor for Use with Implantable Fiducial MarkersInventorsJohn SongFri, 20 Mar 2009 14:27:15 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1599http://vanderbilt.technologypublisher.com/technology/1598ForecastED is a discrete event simulation that was developed and validated for the specific purpose of forecasting near-future emergency department crowding. It was designed to integrate with an existing real-time patient tracking application to provide continually updated crowding forecasts through a graphical web interface, enabling decisions by administrators and providers to address crowding in a proactive - rather than reactive - manner. It has been extensively validated, including a prospective study at its institution of origin and a retrospective study at five external sites throughout...Fri, 20 Mar 2009 14:27:15 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1598http://vanderbilt.technologypublisher.com/technology/1597Nanometer-sized, low-cost, readily available, particulate nanodiamond is used as an additive to the mineral oil used in electrical power transformers and other oil-cooled electrical equipment to enhance the thermal conductivity [TC] and dielectric properties of the oil without compromising the oil’s required electrical insulation, such that failures are suppressed, oil life is greatly extended and load boundaries are elevated. This could extend transformer life and allow increases to transformer MVA ratings.Supplemental DocumentsVU0319--Nanofluid for Cooling Enhancement of Electrical Power Equ...Fri, 20 Mar 2009 14:27:14 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1597http://vanderbilt.technologypublisher.com/technology/1594Vanderbilt researchers have developed a method for generating a novel polymeric material. These materials contain relatively inexpensive carbon nanofiber additives that enhance the mechanical strength of polymer composites by as much as 45%, while adding less than 1 wt% to the material. By adjusting the synthesis process, other polymeric materials may also be created with enhanced thermal, electrical or optical properties. This novel method and material allow one to design new composite materials for a specific product. A key feature of this discovery is attaining covalent bonding across the c...Fri, 20 Mar 2009 14:27:13 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1594http://vanderbilt.technologypublisher.com/technology/1593In previous results, Vanderbilt researchers have demonstrated that t-DARPP is an oncogene that transforms primary mouse embryonic fibroblasts. These researchers have now shown that over-expression of t-DARPP in several cancer subtypes including breast, gastric, and esophageal adenocarcinomas. They have also shown that t-DARPP expression mediates resistance to trastuzumab in breast cancer. The knockdown of t-DARPP can cause cancer cells to die and can dramatically reduce tumors in mice. These results suggest that t-DARPP may be a novel therapeutic agent for the treatment of cancer.Supplemental ...Fri, 20 Mar 2009 14:27:12 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1593http://vanderbilt.technologypublisher.com/technology/1591NanoBioreactors recreate the microenvironments of normal tissue, non-adherent cells, tumor-infected tissue and wounded tissue in vitro. These microfabricated bioreactors provide independent control of chemokine and growth factor gradients, shear forces, cellular perfusion and the permeability of physical barriers to cellular migration. This fine control allows detailed optical and electrochemical observations of normal, immune and cancerous cells during activation, division, cell migration, intravasation, extravasation and angiogenesis.Supplemental DocumentsVU0310--NanoBioreactors for Cellular...Fri, 20 Mar 2009 14:27:11 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1591http://vanderbilt.technologypublisher.com/technology/1590Vanderbilt researchers findings provide a path to the development of novel medications for the treatment of 5HT-related disorders such as major depression, OCD, anxiety, autism and migraine, just to name a few. They suggest that blockade of SERT upregulation, rather than direct SERT blockade, will offer novel opportunities to provide for prevention of inappropriate SERT upregulation without compromising normal SERT function.Supplemental DocumentsVU06109--A3 Adenosine Receptors as Targets for the Modulation of Central Serotonergic SignalingInventorsRandy BlakelyWilliam HewlettChong-Bin ZhuFri, 20 Mar 2009 14:27:10 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1590http://vanderbilt.technologypublisher.com/technology/1589Currently, all SERT-based therapeutics fail to take into account or utilize regulatory pathways, whereas SERT mutation screening may be warranted to establish whether altered regulation underlies a clinical syndrome. Vanderbilt researchers’ findings, including the mutations that disrupt regulation, now provide physical proof that regulation can be disrupted directly via structural changes in SERT, which for the first time means that altered 5-HT transport activity is due to SERT itself.Supplemental DocumentsVU0540--Regulation of Biogenic Antidepressant-Sensitive Serotonin TransportersInventors...Fri, 20 Mar 2009 14:27:10 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1589http://vanderbilt.technologypublisher.com/technology/1588Vanderbilt researchers report the isolation and characterization of a human cDNA encoding the high affinity, hemicholinium-3 sensitive choline transporter. This transporter is expressed in cholinergic terminals, and it provides for transport into cholinergic terminals of choline, the precursor for acetylcholine biosynthesis. The cDNA, through HC-3 radioligand binding assays or choline transport assays, allows for high-throughput screening of choline transporter directed agents or as a negative screen to insure specificity for nicotinic and muscarinic acetylcholine receptor-directed agents (as ...Fri, 20 Mar 2009 14:27:09 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1588http://vanderbilt.technologypublisher.com/technology/1586Vanderbilt researchers have correlated a high calcium/magnesium intake ratio and an allele in the TRPM7 with colorectal cancer. Coupled together, these may serve as biomarkers for the prediction of an elevated risk of colorectal cancer.Supplemental DocumentsVU0715--Biomarkers for Magnesium DeficiencyInventorsQi DaiMartha ShrubsoleWei ZhengFri, 20 Mar 2009 14:27:09 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1586http://vanderbilt.technologypublisher.com/technology/1584This technology enables the delivery of biological molecules into the interior of a cell. Such a delivery mechanism could be utilized in a variety of therapies including peptide, gene transfer and/or antisense therapy. InventorsJack HawigerYao-Zhong LinFri, 20 Mar 2009 14:27:08 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1584http://vanderbilt.technologypublisher.com/technology/1582Vanderbilt scientists have discovered that the receptor tyrosine phosphatase DEP-1 plays a significant role in angiogenesis and that modulation of the DEP-1 receptor with certain agents can affect endothelial cell growth. The research team has developed antibodies that bind to the ectodomain of a mammalian transmembrane protein known as DEP-1 (for density enhanced protein) or CD148. CD148 (also named DEP-1/PTPn) is a receptor-like protein tyrosine phosphatase that is abundantly expressed in vascular endothelial cells, hematopoietic-cell lineages, duct epithelia of thyroid, mammary and gastro...Fri, 20 Mar 2009 14:27:07 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1582http://vanderbilt.technologypublisher.com/technology/1581Fri, 20 Mar 2009 14:27:06 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1581http://vanderbilt.technologypublisher.com/technology/1579Vanderbilt researchers have developed a novel single-voxel localization technique for Magnetic Resonance Spectroscopy (MRS), termed ASSESS (Arbitrary Shape Selective Excitation Summed Spectroscopy). ASSESS can measure spectra from regions of arbitrary shape allowing the user to customize the region of interest.Supplemental DocumentsVU07143--Arbitrary Shape Selective Excitation Summed Spectroscopy (ASSESS)InventorsRobin de GraafJohn GoreQin QinFri, 20 Mar 2009 14:27:05 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1579http://vanderbilt.technologypublisher.com/technology/1578This invention identifies COX-2 metabolites as markers for a variety of inflammatory, neurodegenerative and cancerous diseases, and it provides a means for determining and monitoring levels of metabolites of COX-2 from patient samples. It may also be used to augment information from imaging and other diagnostic and disease progression monitoring modalities. In addition, the technology provides a means for testing activity of agonists or antagonists that can aid in the design of drugs that reduce effects of harmful prostaglandins with reduced side effects. Supplemental DocumentsVU0057--Assays t...Fri, 20 Mar 2009 14:27:05 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1578http://vanderbilt.technologypublisher.com/technology/1577Autism spectrum disorders are common and are reported to have a population prevalence of ~1/300- 1/500. The Sutcliffe laboratory, in collaboration with the Blakely laboratory, has identifi ed the serotonin transporter gene (gene symbol: SLC6A4; protein: hSERT) as being a genetic risk locus for autism and autism spectrum disorders. This would represent the first autism gene to be described in which functionally abnormal alleles confer genetic risk for this common developmental disorder. Based on our current findings, this gene appears to confer risk that affects a signifi cant number of familie...Fri, 20 Mar 2009 14:27:04 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1577http://vanderbilt.technologypublisher.com/technology/1576Norepinephrine transporters (NETs) inactivate the sympathetic and brain neurotransmitter norepinephrine (NE) after release and are major targets for cocaine, amphetamines and antidepressants. NETs are closely related to antidepressant-sensitive serotonin transporters (SERTs) and cocaine-sensitive dopamine transporters (DATs). We have discovered that NETs are ubiquitinated under basal conditions and that this ubiquitination can be enhanced by stimuli that trigger NET endocytosis.Supplemental DocumentsVU0557--Regulation of Biogenic Amine Neurotransmitter Transporters by UbiquitinationInventorsR...Fri, 20 Mar 2009 14:27:04 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1576http://vanderbilt.technologypublisher.com/technology/1575Vanderbilt researchers have identified a potential biomarker for Alzheimer’s disease. Preliminary results from human central spinal fluid samples indicate that this biomarker could be used prior to tissue loss allowing early diagnosis.Supplemental DocumentsVU08125--Biomarkers for Alzheimer's DiseaseInventorsOlivier BoutaudFri, 20 Mar 2009 14:27:03 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1575http://vanderbilt.technologypublisher.com/technology/1574InTiGen is developing products for bone and cartilage regeneration based on the “in vivo bioreactor” (IVB) technology developed at MIT and Vanderbilt University. These products require no growth factors or other drugs, no cell transplantation and require only minimally invasive (outpatient) surgical techniques. As such, the company is well suited to meet a large unmet need in a market in excess of $800 million in the U.S. alone. Supplemental DocumentsVU0711--In Vivo Cartilage EngineeringInventorsPieter EmansV. Prasad ShastriFri, 20 Mar 2009 14:27:03 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1574http://vanderbilt.technologypublisher.com/technology/1573Vanderbilt researchers have designed a cell line with stable expression of the human heart potassium channel, HERG. This cell line has robust and very consistent cell-to-cell HERG activity without detectable endogenous ionic currents, making it ideal to use in preclinical drug screening.Supplemental DocumentsVU0918--Stable HERG Expressing CellsInventorsAlfred GeorgeCarlos VanoyeFri, 20 Mar 2009 14:27:02 GMTlee.bridges@vanderbilt.eduhttp://vanderbilt.technologypublisher.com/technology/1573