Search Results - therapeutics

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Novel Curcumin Derivatives with Enhanced Anti-Inflammatory Properties

SUMMARY This technology comprises two novel curcumin derivatives - compounds D3 and D4 - with potent anti-inflammatory properties. These compounds effectively inhibit a key inflammatory signaling pathway, offering enhanced therapeutic potential over traditional curcumin. The technology provides improved bioactive compounds for nutraceutical and pharmaceutical...

Published: 12/9/2025 | Inventor(s):

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Category(s): Natural Products, Research Tools, Therapeutics

Genetic engineering approach for enhancing recombinant protein production by mammalian cells

Summary Vanderbilt researchers have developed a novel approach to enhance recombinant protein production in mammalian cell culture systems through metabolic engineering. By overexpressing specific metabolic proteins in these cells, this technology achieves higher monoclonal antibody titers and increased cell-specific productivity compared to conventional...

Published: 12/9/2025 | Inventor(s):

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Category(s): Biomanufacturing, Research Tools, Therapeutics

Oxygen-Tolerant Probiotic Therapy for Intestinal Inflammatory Diseases

Summary Anaerobic bacteria used in current probiotic compositions cannot tolerate the oxygen stress found in the gut during inflammation, reducing their effectiveness in restoring a healthy gut microbiome. Vanderbilt researchers have engineered Bacteroides thetaiotaomicron, an obligate anaerobe, to endure oxygen-rich conditions in the gut. This advancement...

Published: 12/2/2025 | Inventor(s):

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Category(s): Research Tools, Therapeutics

Human antibodies targeting a novel flu epitope for use as a universal flu vaccine and treatment

Technology Summary: Scientists at Vanderbilt have discovered a new class of human antibodies specific to a novel target for the detection, prevention, and treatment of influenza A viruses (IAV). Using structural characterization, they have identified a novel antigenic site on the hemagglutin (HA) head domain that may be targeted by multiple antibodies...

Published: 8/28/2025 | Inventor(s):

Keywords(s): Infectious Disease

Category(s): Therapeutics, Vaccines

Targeting PD-1H to treat Acute Myeloid Leukemia (AML)

Summary Despite the success of immune checkpoint inhibitors (ICI) like anti-PD-1 in treating other cancers, these therapeutics have not been demonstrated to effectively treat acute myeloid leukemia (AML). Vanderbilt researchers have identified PD-1H as a potential target for treating AML, opening the door for effective therapy using an ICI molecule. Addressed...

Published: 8/28/2025 | Inventor(s):

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Category(s): Therapeutics

Novel Growth Factor for Liver Regeneration

Summary Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadly implementing this approach. Vanderbilt University researchers have identified a growth factor that promotes...

Published: 5/7/2025 | Inventor(s):

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Category(s): Research Tools, Therapeutics

Oral administration of levocarnitine for treating Sjögren’s Syndrome-associated dry eye

Summary Sjögren’s syndrome (SjS) is a debilitating autoimmune disease, causing dry eye symptoms ranging from discomfort to dysfunction. Vanderbilt researchers have identified levocarnitine as a novel potential therapeutic for treating this condition. Addressed Need SjS is one of the most prevalent autoimmune diseases, affecting the exocrine...

Published: 2/15/2024 | Inventor(s):

Keywords(s): Opthamology

Category(s): Natural Products, Therapeutics

Anti-inflammatory microparticles for sustained ocular drug delivery

Summary Vanderbilt researchers have developed an injectable drug delivery vehicle using microparticles (MPs) that can deliver cargos in the eye for at least 6 weeks while also playing a therapeutic role in reducing inflammation. Addressed Need Targeted delivery of anti-inflammatory drugs could be used to treat many ocular diseases, including glaucoma...

Published: 2/1/2024 | Inventor(s):

Keywords(s): Inflammatory/Immune/Wound Repair, Opthamology

Category(s): Therapeutics

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Summary Researchers at Vanderbilt University have generated a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses. Addressed Need In recent years, adoptive...

Published: 1/18/2024 | Inventor(s):

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Category(s): Therapeutics, Research Tools

Targeted light-based therapy for acne

Summary Acne is the most common skin condition, with direct treatment costs totaling over $3 billion each year. Vanderbilt researchers have developed a photodynamic therapy (PDT) for effectively and specifically treating Propionibacterium acnes infections, enabling improved clinical support for patients. Addressed Need More than 90% of the global...

Published: 9/4/2024 | Inventor(s):

Keywords(s): Dermatology, Infectious Disease

Category(s): Therapeutics

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