Search Results - therapeutics

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Novel Growth Factor for Liver Regeneration

Summary Liver transplantation is the only cure for end-stage liver disease, but donor organ scarcity limits access for millions. Split liver transplantation could help bridge this gap, but the regeneration of partial organs is critical to broadly implementing this approach. Vanderbilt University researchers have identified a growth factor that promotes...

Published: 11/21/2024 | Inventor(s):

Keywords(s):

Category(s): Research Tools, Therapeutics

Oral administration of levocarnitine for treating Sjögren’s Syndrome-associated dry eye

Summary Sjögren’s syndrome (SjS) is a debilitating autoimmune disease, causing dry eye symptoms ranging from discomfort to dysfunction. Vanderbilt researchers have identified levocarnitine as a novel potential therapeutic for treating this condition. Addressed Need SjS is one of the most prevalent autoimmune diseases, affecting the exocrine...

Published: 2/15/2024 | Inventor(s):

Keywords(s): Opthamology

Category(s): Natural Products, Therapeutics

Anti-inflammatory microparticles for sustained ocular drug delivery

Summary Vanderbilt researchers have developed an injectable drug delivery vehicle using microparticles (MPs) that can deliver cargos in the eye for at least 6 weeks while also playing a therapeutic role in reducing inflammation. Addressed Need Targeted delivery of anti-inflammatory drugs could be used to treat many ocular diseases, including glaucoma...

Published: 2/1/2024 | Inventor(s):

Keywords(s): Inflammatory/Immune/Wound Repair, Opthamology

Category(s): Therapeutics

Use of Fluid Shear Stress Treatment to Enhance T Cell Activation

Summary Researchers at Vanderbilt University have generated a technique to enhance immune cell activation by exposing cells to mechanical force while culturing. Proof-of-concept data indicate that activating immune cells with this method may improve therapeutic efficacy and reduce manufacturing expenses. Addressed Need In recent years, adoptive...

Published: 1/18/2024 | Inventor(s):

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Category(s): Therapeutics, Research Tools

Targeted light-based therapy for acne

Summary Acne is the most common skin condition, with direct treatment costs totaling over $3 billion each year. Vanderbilt researchers have developed a photodynamic therapy (PDT) for effectively and specifically treating Propionibacterium acnes infections, enabling improved clinical support for patients. Addressed Need More than 90% of the global...

Published: 9/4/2024 | Inventor(s):

Keywords(s): Dermatology, Infectious Disease

Category(s): Therapeutics

Protein that protects probiotics from desiccation, leading to improved gut colonization

Summary Probiotic supplements undergo significant water loss before consumption, killing many of their bacteria and rendering them less effective. Vanderbilt researchers have discovered a protein that protects against damage caused by desiccation and shown that this molecular shield can be added to probiotics to help them survive and colonize the gut....

Published: 12/19/2022 | Inventor(s):

Keywords(s): Gastrointestinal

Category(s): Therapeutics

Targeted photodynamic therapy for S. aureus infections

Summary Staphylococcus aureus is among the most prevalent pathogens in skin and soft tissue infections, with treatments becoming increasingly compromised by the emergence of methicillin-resistant S. aureus (MRSA). Vanderbilt researchers have developed a combination photodynamic therapy (PDT) for targeting MRSA infections in skin that is not only effective...

Published: 8/9/2023 | Inventor(s):

Keywords(s): Dermatology, Infectious Disease

Category(s): Therapeutics

An Ergothioneine PET Radioligand for Imaging Oxidative Stress in Alzheimer’s Disease

Summary Vanderbilt researchers lead by Professor Wellington Pham, PhD, have developed a novel ergothioneine (ERGO) PET radioligand for imaging oxidative stress in Alzheimer’s disease. Addressed Need Alzheimer’s disease (AD) afflicts more than six million Americans alone every day, with no cure in sight. Ergothioneine however, is an amino...

Published: 12/3/2021 | Inventor(s):

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Category(s): Therapeutics

Cooling-Responsive Gel for Local Drug Delivery Applications

Addressed Need Local drug delivery has emerged as a promising strategy for pain management, cancer treatment, and more. Conventional drug therapies enter systemic circulation which is susceptible to off-target effects and rapid elimination from the body. Even more concerning, clinicians are seeking pain management alternatives to narcotics in light...

Published: 8/4/2021 | Inventor(s):

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Category(s): Therapeutics

Vascular Restoration Therapy with Cell-Penetrating CRADD Protein

Addressed NeedVascular inflammation caused by metabolic, autoimmune, and microbial insults mediates cardiovascular diseases that include hypertension and atherosclerosis (heart attacks, strokes), systemic lupus, and giant cell arteritis. An estimated 35 million Americans have hypercholesterolemia, contributing to 500,000 deaths underlying heart attacks...

Published: 2/7/2023 | Inventor(s):

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Category(s): Therapeutics

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